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Metal-ligand covalency in uranium, thorium, and cerium coordination chemistry: elucidating the nature of chemical bonding in f-element complexes using phosphorus ligands
(2022-05-13)
Herein the syntheses and characterization of model actinide and lanthanide complexes bearing phosphorus-based ligands are reported. High-symmetry molecular models featuring phosphorus-based ligands are very advantageous ...
Machine learning assisted molecular simulations / mass spectrometry data analysis and rational design of antibacterial Co3O4 nanowires flagella
(2023-05-12)
In chapter one, inspired by the recent work from Noé and coworkers on the development of machine learning based implicit solvent model for the simulation of solvated peptides [Chen et al., J. Chem. Phys. 155, 084101 (2021)], ...
Quantifying the intact proteome: optimization of analytical methods for high-throughput top-down proteomics
(2023-05-12)
Proteins play an indispensable cellular role within organisms and participate in a majority of biological functions, including enzymatic catalysis, immune reaction, and signaling. Multiple forms of a protein (i.e., ...
Single Cell Mass Spectrometry Metabolomics Study of Drug-resistant Cells
(2022-05-13)
Single cell analysis is an emerging area to reveal the heterogeneity of individual cells among all populations. Understanding the cell-to-cell variation can greatly promote the development of drug discovery, disease ...
Cascade Reactions to Access Bioactive Scaffolds
(2020-07-16)
In the recent decade there has been a shift in drug development to favor planar, aromatic small molecules with easy synthetic access, despite centuries of research in bioactive natural products, which are often highly ...
Bioactive Molecules Detection and Identification in Complex Biological Systems through Activity-Based Metabolomics and Proteomics
(2020-07)
The detection and identification of bioactive molecules (e.g. therapeutic small-molecule lead compounds, functional proteins) from complex mixtures is often a critical step in various biochemical and biomedical research ...
Protein engineering of Cas9 for safer genome tools, and phylogenetic analysis of Coronavirus spike protein for efficient antiviral targets
(2022-12-16)
Clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated (Cas) proteins are adaptive immune systems that protect bacteria and archaea from mobile genetic elements. These systems have been ...
The Advancement of Narrow Open Tubular Liquid Chromatography
(2021-12-17)
Open tubular columns are primarily used in gas chromatography, and they were regarded as the best choice to achieve high separation efficiency in gas chromatography. Substances diffuse much slower in liquids than in gases. ...
DEVELOPMENT AND APPLICATION OF SINGLE CELL MASS SPECTROMETRY TECHNIQUES FOR NON-ADHERENT CELL ANALYSIS
(2020-07)
Mass spectrometry (MS) analysis of biological samples is traditionally carried out using extractions from large populations of cells, concealing the information from individual cells. In contrast, the drawbacks of traditional ...
Chemical Genetics and Molecular Pharmacology of the Oxysterol-Binding Proteins
(2020-07)
Oxysterol-binding protein (OSBP) and the OSBP-related proteins (ORPs) comprise a family of lipid-binding proteins organized into 6 subfamilies in humans. ORP subfamily 1 consists of OSBP and its closest homolog, ORP4. OSBP ...