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The Advancement of Narrow Open Tubular Liquid Chromatography
(2021-12-17)
Open tubular columns are primarily used in gas chromatography, and they were regarded as the best choice to achieve high separation efficiency in gas chromatography. Substances diffuse much slower in liquids than in gases. ...
Elucidating the mechanisms of DNA cleavage by CRISPR effector proteins, Cas9 and Cas12a
(2021-05-14)
CRISPR-Cas systems are adaptive immune systems protecting bacteria and archaea against
intruding genetic elements. Of the different types, the signature nucleases of type II and type VA, Cas9 and Cas12a, are popular choices ...
Applications of Button Sample Holders for Mid-Infrared Spectroscopy Measurements
(2021-12-17)
Infrared (IR) spectroscopy is a rapid and non-destructive method for chemical analysis that is based on interactions between electromagnetic radiation and matter. Despite its widespread popularity in commercial and research ...
Development and application of spray-capillary, a novel device for microsampling, and online capillary zone electrophoresis mass spectrometry analysis on nanoscale omics study
(2021-12-17)
The capillary zone electrophoresis-mass spectrometry (CZE-MS) platform, a well-developed analytical methodology, has been widely used for high-throughput nanoscale (e.g., < 5000 cells, single-cell sample) bioanalysis (e.g., ...
Metabolomic and phylogenetic analyses to better inform the construction of natural products discovery libraries
(2021-08-05)
Natural product discovery programs rely on diverse libraries of organisms to provide access to a diverse pool of compounds. The quality and chemical diversity of these libraries are therefore of utmost importance to the ...
Developments of high-throughput quantitative top-down proteomics
(2021-12-17)
The LC-MS techniques are commonly used to analyze intact proteoforms for top-down proteomics. To deepen the coverage of the intact human proteome, multidimensional separations are often applied prior to the MS analysis. ...
Chemoenzymatic Transformations of Indole and Azaindole Containing Natural Product Analogs Using Promiscuous Prenyltransferases
(2021-12-17)
The overall aim of my work was to expand the practical utility of prenyltransferase-based biocatalysis as a tool in organic synthesis, natural product diversification, and drug discovery efforts. Aromatic prenyltransferases ...
Polyviologen-modified anodes for carbohydrate biofuel cells
(2021-05-14)
Polyalkylviologens (PVCn (n = 2 - 6)) were successfully deposited on glassy carbon electrodes (GCEs) by electropolymerization of bis(4-cyano-1-pyridino)-alkane dibromides (PyCnBr2 (n = 2 - 6)) as precursors. By studying ...
Computational analysis of substituent effect on emission wavelengths and chemical reaction rates
(2021-12-17)
Substituent groups are widely used to take advantage of their electronic and steric proper- ties. For example, substituents with an electron-donating or electron-withdrawing nature have been utilized to design new materials ...