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Investigations of secondary metabolites from fungi: isolation, structure elucidation, and semi-synthetic studies
(2022-12-16)
Trichomoniasis, caused by Trichomonas vaginalis remains a worldwide threat, afflicting an astonishing 3.9% of the world’s population. This parasite is recognized as a cause of vaginitis and can result in serious health ...
Detailed analysis of protein-DNA interactions driving type II-A CRISPR adaptation
(2020-08)
CRISPR-Cas is an adaptive immune system that protects prokaryotes against foreign nucleic acids. Prokaryotes gain immunity by acquiring short pieces of the invading nucleic acid, termed prespacers, and inserting them into ...
Chemoenzymatic Transformations of Indole and Azaindole Containing Natural Product Analogs Using Promiscuous Prenyltransferases
(2021-12-17)
The overall aim of my work was to expand the practical utility of prenyltransferase-based biocatalysis as a tool in organic synthesis, natural product diversification, and drug discovery efforts. Aromatic prenyltransferases ...
Efforts towards the synthesis of furan containing bioactive compounds
(2023-12-15)
Furan is a valuable subunit in pharmaceutical chemistry. However, there are still
challenges in synthesizing furan-containing compounds. Two approaches have been
attempted to address this issue. 1. Using enynal molecules ...
Creation of Hyper-Doped Crystalline Titania Thin Films by the Kinetic Doping Method for Solar Cell Anode Material
(2022-12-16)
This work outlines the general process of kinetic doping and how its benefits have been expanded from silica-based applications to use in titania thin films. While this has potential for many applications, the utilization ...
Polyviologen-modified anodes for carbohydrate biofuel cells
(2021-05-14)
Polyalkylviologens (PVCn (n = 2 - 6)) were successfully deposited on glassy carbon electrodes (GCEs) by electropolymerization of bis(4-cyano-1-pyridino)-alkane dibromides (PyCnBr2 (n = 2 - 6)) as precursors. By studying ...
Personalized medicine: developing precision antiviral/ anticancer therapeutics and bio-analytical chemotherapeutic drug monitoring
(2020)
Personalized medicine, also known as precision medicine, is a broad medical paradigm for tailoring patients’ treatments based upon their individual biological makeup to produce the most effective, safest clinical outcomes. ...
Bacteriophage-based biomaterials for manipulating derivation and differentiation of human induced pluripotent stem cells
(2020-05)
Induced pluripotent stem cells (iPSCs), which are derived from somatic cells, can differentiate into any cell type. They are promising tools in medical applications including regenerative medicine, personalized cell therapy, ...
Computational analysis of substituent effect on emission wavelengths and chemical reaction rates
(2021-12-17)
Substituent groups are widely used to take advantage of their electronic and steric proper- ties. For example, substituents with an electron-donating or electron-withdrawing nature have been utilized to design new materials ...
Mass spectrometry-based metabolomics analysis of Chagas disease models
(2024-05-10)
Chagas disease (CD) is a neglected tropical disease which is caused by the parasite Trypanosoma cruzi. Approximately 6 to 7 million people in the world are infected with T. cruzi. The symptoms at the acute phase are mild ...