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Purification, Mechanism, and Biochemical Interactions of the Essential Mycolic Acid Transporters MmpL3 from Mycobacterium tuberculosis, and CmpL1 from Corynebacterium glutamicum.
(2020-06)
The Corynebacterium – Mycobacterium – Nocardia family (CMN family) are a subset group of actinomycetes which are characterized as acid-fast, Gram-positive species. Many members of the CMN family are causative agents of ...
Fundamental and Translational Applications of LC-MS/MS Based Metabolomics in Infectious Diseases
(2022-05-13)
Metabolomics is the study of small molecules (metabolites) <1500 Da. It combines analytical and biochemical techniques to help understand disease pathogenesis. Metabolites also change dynamically in response to disease and ...
HARNESSING SMALL-MOLECULE PROTEIN STIMULATION TO DEVELOP NEW LEADS FOR RETINAL AND INFECTIOUS DISEASES
(2020-07)
This dissertation describes the development of new therapeutic leads for retinal (chapter 1-3) and infectious diseases (chapter 4). More than 40% of patients with retinal inflammatory diseases are refractory to the standard ...
Immunological and biochemical investigation of branched polyethylenimines to neutralize PAMP-induced inflammation, eradicate multidrug-resistant biofilms, and broaden antibiotic spectrum in acute and chronic wounds
(2023-08-03)
Innate immunity has considerable specificity and can discriminate between individual species of microbes. In this regard, pathogens are “seen” as dangerous to the host and elicit an inflammatory response capable of destroying ...
Lipid-based nanoparticles for tissue regeneration and cancer photothermal therapy
(2020-05-07)
Exosome, a cell budded nanovesicle in diameter around 30 nm to 200 nm, has been found useful for the gene and drug delivery in bone tissue regeneration and cancer therapy. Exosome derived from donor cells has some specific ...
Developments of high-throughput quantitative top-down proteomics
(2021-12-17)
The LC-MS techniques are commonly used to analyze intact proteoforms for top-down proteomics. To deepen the coverage of the intact human proteome, multidimensional separations are often applied prior to the MS analysis. ...
Application of kinetic doping of silica sol-gel thin films to internal coating of capillary tubes and doping of branched polyethylenimine
(2020-05)
The applications of kinetic doping in silica sol-gel thin films are a mostly under-developed area. Previously, our lab has demonstrated a high loading capacity for cationic dye and protein guest molecules in silica thin ...
Development of synthetic methodologies for N- to C-terminal cyclization of peptidomimetic small molecules and in silico and in vitro studies of the role of cyclization on antibacterial and antiviral activities
(2022-05-13)
Among the different mechanisms of resistance in Gram-negative bacteria, the permeability barrier of the outer membrane and efflux pumps represent a significant challenge to address as they synergize to reduce accumulation ...
Characterization of a Sporulation Related Two-Component Signaling System in Clostridioides difficile
(2023-12-15)
Clostridioides difficile is a spore-forming anaerobic human pathogen, that is commonly associated with antibiotic therapy in adults. The disturbance of the gut microbiota, typically caused by antibiotics, allows for an ...
Nanomaterial based non-invasive cancer diagnosis methods: cancer imaging and small RNA quantification
(2020-12)
Cancer is a worldwide disease and causes millions of deaths every year. The fatality of cancer is responsible for approximating a sixth of global death. To reduce cancer mortality, early diagnosis is one of the key factors. ...