Search
Now showing items 1-10 of 13
Metal-ligand covalency in uranium, thorium, and cerium coordination chemistry: elucidating the nature of chemical bonding in f-element complexes using phosphorus ligands
(2022-05-13)
Herein the syntheses and characterization of model actinide and lanthanide complexes bearing phosphorus-based ligands are reported. High-symmetry molecular models featuring phosphorus-based ligands are very advantageous ...
Single Cell Mass Spectrometry Metabolomics Study of Drug-resistant Cells
(2022-05-13)
Single cell analysis is an emerging area to reveal the heterogeneity of individual cells among all populations. Understanding the cell-to-cell variation can greatly promote the development of drug discovery, disease ...
Protein engineering of Cas9 for safer genome tools, and phylogenetic analysis of Coronavirus spike protein for efficient antiviral targets
(2022-12-16)
Clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated (Cas) proteins are adaptive immune systems that protect bacteria and archaea from mobile genetic elements. These systems have been ...
Harnessing metal carbenoids to assemble spirocycles and glycans
(2022-08-04)
Within the realm of drug discovery more intricate, rigid small molecules exhibit higher potencies as drug leads and candidates. This is because molecules with three-dimensional features such as stereochemistry and bond ...
Low-molecular-weight branched polyethylenimines: Multifunctional beta-lactam potentiators against resistant Gram-negative pathogens
(2022-05-13)
Antibiotic resistance is a simmering threat to the global public health system. Currently, it is estimated by the Centers for Disease Control and Prevention that at least 2.8 million people in the US get infected with ...
Development of Novel Material Design Strategies for High-Efficiency and Tunable Photoluminescence Properties
(2022-12-16)
New developments in the understanding of structural-optical property relationships of optoelectronic materials have led to rapid growth in energy-efficient solid-state lighting technologies. These improvements in the field ...
New applications of molybdenum (VI) catalyzed oxygen atom transfer reactions
(2022-12-16)
The chemistry of dioxomolybdenum coordination complexes has been deeply investigated as a model for molybdoenzyme structure and activity, as well as for non-biological chemical applications. In this work, we present ...
Synthesis and Redox Behavior of Ruthenium Nitrosyl Porphyrin Complexes
(2022-05-13)
This dissertation details the synthesis, characterization, and redox behavior of various six-coordinate ruthenium nitrosyl porphyrin complexes. The primary focus of this work is centered on factors that impact the redox ...
Small molecule design strategies for probing structure-activity relationships: bacterial virulence modulation via CpxRA, the total synthesis of Picrasma alkaloids, and coronavirus main protease inhibitors
(2022-05-13)
The overall aim of this work is to contribute to molecular design strategies for early lead development while probing structure-activity relationships via the design and synthesis of small molecules. This dissertation will ...
Fundamental and Translational Applications of LC-MS/MS Based Metabolomics in Infectious Diseases
(2022-05-13)
Metabolomics is the study of small molecules (metabolites) <1500 Da. It combines analytical and biochemical techniques to help understand disease pathogenesis. Metabolites also change dynamically in response to disease and ...