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Machine learning assisted molecular simulations / mass spectrometry data analysis and rational design of antibacterial Co3O4 nanowires flagella
(2023-05-12)
In chapter one, inspired by the recent work from Noé and coworkers on the development of machine learning based implicit solvent model for the simulation of solvated peptides [Chen et al., J. Chem. Phys. 155, 084101 (2021)], ...
Quantifying the intact proteome: optimization of analytical methods for high-throughput top-down proteomics
(2023-05-12)
Proteins play an indispensable cellular role within organisms and participate in a majority of biological functions, including enzymatic catalysis, immune reaction, and signaling. Multiple forms of a protein (i.e., ...
Single-probe Single Cell Mass Spectrometry Studies: Investigation of Cell Heterogeneity and Quantification of Intracellular Small Molecules
(2023-12-15)
Studying cell heterogeneity can provide a deeper understanding of biological activities, but corresponding studies cannot be performed using traditional bulk analysis methods. The development of diverse single cell bioanalysis ...
Development and application of high throughput hydrogen deuterium exchange mass spectrometry for characterizing protein interactions in complex biological samples
(2023-05-12)
Protein interactions (e.g., protein-protein interactions and protein-ligand interactions) play an important role in regulating the numerous biological processes that dictate cellular activity. The characterization of protein ...
Characterization of the protein-protein interactions of the type-II toxin-antitoxin system ParDE1 from Pseudomonas aeruginosa
(2023-05-12)
The emergence of multidrug-resistant bacteria has led to an ever-growing antibiotic resistance crisis. To combat this growing crisis, new strategies for controlling bacterial cell growth must be developed. An underdeveloped ...
Exploring cell heterogeneity: applications of single-probe single cell mass spectrometry for subpopulation analysis
(2023-12-15)
Mass spectrometry (MS) has become an indispensable tool for transformed metabolomics studies, whereas exploring single-cell metabolomic profiles remains a challenge due to limited techniques and suitable algorithms. This ...
Enzymatic and non-enzymatic bioanodes: novel materials for glucose oxidase and polyviologen biosensors and biofuel cells
(2023-12-15)
A fundamental study of the interaction of iodide and glucose oxidase (GOx) was carried out, showing that the iodide acts as a direct mediator with GOx in enzymatic glucose biosensors. This direct mediation may be happening ...
Using Novel Data Analysis Methods to Extract Information from Mass Spectrometry Imaging and Single Cell Mass Spectrometry Results
(2023-12-15)
Mass spectrometry (MS) is a powerful tool for qualitative and quantitative biological sample analysis, with its high sensitivity, broad applicability, and strong robustness. While insights into ‘what’ and ‘how’ can be ...
Immunological and biochemical investigation of branched polyethylenimines to neutralize PAMP-induced inflammation, eradicate multidrug-resistant biofilms, and broaden antibiotic spectrum in acute and chronic wounds
(2023-08-03)
Innate immunity has considerable specificity and can discriminate between individual species of microbes. In this regard, pathogens are “seen” as dangerous to the host and elicit an inflammatory response capable of destroying ...
Characterization of a Sporulation Related Two-Component Signaling System in Clostridioides difficile
(2023-12-15)
Clostridioides difficile is a spore-forming anaerobic human pathogen, that is commonly associated with antibiotic therapy in adults. The disturbance of the gut microbiota, typically caused by antibiotics, allows for an ...