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Genetic and biochemical characterization of hydroxamate transporters in Listeria monocytogenes.
(2007)
Listeria monocytogenes is a Gram-positive bacterial pathogen that can cause severe opportunistic infection in humans and animals, and iron is a virulence determinant in this pathogen. By sequence homologies, the genome of ...
Site-directed mutagenesis as a probe to study the mechanism of sheep liver 6-phosphogluconate dehydrogenase.
(2006)
All mutant enzymes in the 2'-phosphate site exhibit an increase in KNADP that ranges from 6-fold to 80-fold. A 7-fold increase in the primary kinetic 13C-isotope effect minus 1 in all mutant enzymes indicates that the ...
Investigation into the in vivo metabolism of glutathionyl conjugates of dopamine and norepinephrine: Possible insights into neurodegenerative diseases.
(1997)
The in vitro and in vivo hydrolyses of 5-S-Glu-NE were investigated in rat brain homogenates and by intracerebroventricular (icv) administration in rat brains. Under in vitro conditions, 5-S-Glu-NE was hydrolyzed to give ...
Comparative sequencing of human and mouse syntenic regions from DGCR and MND2.
(1999)
With successful implementation of the shotgun sequencing strategy, two syntenic regions between human and mouse, totaling about 0.8 Mb, have been sequenced. One is from the DiGeorge syndrome critical region (DGCR) from ...
Sequencing analysis of regions of human chromosomes 11 and 22: Meningioma (22), cat eye syndrome (22), and multiple endocrine neoplasia, type 1 (11).
(1997)
The complete nucleotide sequence of a meningioma deletion region (MDR) from human chromosome 22q11, a segment of the Cat Eye Syndrome (CES) region from human chromosome 22, and portions of the Multiple Endocrine Neoplasia, ...
The structure and function of YPD1, a histidine-containing phosphotransfer protein from yeast.
(2001)
Finally, through molecular modeling and structural comparisons, a general model of how YPD1 and response regulator domains might interact was proposed. It seems likely that YPD1 binds to response regulator domains through ...
Identification and analysis of the response regulator binding site on the surface of the histidine-containing phosphotransfer protein YPD1 from Saccharomyces cerevisiae.
(2003)
The results from the yeast two-hybrid screens were confirmed by the X-ray crystal structure of the SLN1-R1/YPD1 complex. This structure is the first to reveal protein-protein interactions between a monomeric HPt domain and ...
Characterization of a Sporulation Related Two-Component Signaling System in Clostridioides difficile
(2023-12-15)
Clostridioides difficile is a spore-forming anaerobic human pathogen, that is commonly associated with antibiotic therapy in adults. The disturbance of the gut microbiota, typically caused by antibiotics, allows for an ...