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Enzymatic and non-enzymatic bioanodes: novel materials for glucose oxidase and polyviologen biosensors and biofuel cells
(2023-12-15)
A fundamental study of the interaction of iodide and glucose oxidase (GOx) was carried out, showing that the iodide acts as a direct mediator with GOx in enzymatic glucose biosensors. This direct mediation may be happening ...
New applications of molybdenum (VI) catalyzed oxygen atom transfer reactions
(2022-12-16)
The chemistry of dioxomolybdenum coordination complexes has been deeply investigated as a model for molybdoenzyme structure and activity, as well as for non-biological chemical applications. In this work, we present ...
Synthesis and Redox Behavior of Ruthenium Nitrosyl Porphyrin Complexes
(2022-05-13)
This dissertation details the synthesis, characterization, and redox behavior of various six-coordinate ruthenium nitrosyl porphyrin complexes. The primary focus of this work is centered on factors that impact the redox ...
Development and application of spray-capillary, a novel device for microsampling, and online capillary zone electrophoresis mass spectrometry analysis on nanoscale omics study
(2021-12-17)
The capillary zone electrophoresis-mass spectrometry (CZE-MS) platform, a well-developed analytical methodology, has been widely used for high-throughput nanoscale (e.g., < 5000 cells, single-cell sample) bioanalysis (e.g., ...
ANTIBIOTIC COMBINATION THERAPY AGAINST MULTIDRUG-RESISTANT STAPHYLOCOCCUS EPIDERMIDIS BIOFILMS AND BROADENING ANTIBIOTIC SPECTRUM USING POLYETHYLENIMINE
(2020-07)
Antibiotic resistance (AR) is a serious growing threat around the globe. There has been no new antibiotic class developed in the past 30 years, while antibiotic-resistant superbugs are emerging everywhere and becoming more ...
Using Novel Data Analysis Methods to Extract Information from Mass Spectrometry Imaging and Single Cell Mass Spectrometry Results
(2023-12-15)
Mass spectrometry (MS) is a powerful tool for qualitative and quantitative biological sample analysis, with its high sensitivity, broad applicability, and strong robustness. While insights into ‘what’ and ‘how’ can be ...
Concise synthesis methods to aminosterols and sterol N-glycosides for the development of new OSW-1-derived scaffolds
(2020-05-08)
Abstract
The cholestane glycoside natural product compound OSW-1 has both broad spectrum antiviral activity and potent antiproliferative activity. OSW-1 is a high affinity ligand of both oxysterol-binding protein (OSBP) ...
Metabolomic and phylogenetic analyses to better inform the construction of natural products discovery libraries
(2021-08-05)
Natural product discovery programs rely on diverse libraries of organisms to provide access to a diverse pool of compounds. The quality and chemical diversity of these libraries are therefore of utmost importance to the ...
Small molecule design strategies for probing structure-activity relationships: bacterial virulence modulation via CpxRA, the total synthesis of Picrasma alkaloids, and coronavirus main protease inhibitors
(2022-05-13)
The overall aim of this work is to contribute to molecular design strategies for early lead development while probing structure-activity relationships via the design and synthesis of small molecules. This dissertation will ...
Functions of ARID3a in multiple hematopoietic cell types
(2020-09-18)
Since the completion of the Human Genome Project in 2003, scientists have had a map of all the base pairs that make up human DNA. Beginning in 2008, RNA-seq was developed that allowed scientists to directly sequence messenger ...