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Now showing items 11-20 of 54
Harnessing metal carbenoids to assemble spirocycles and glycans
(2022-08-04)
Within the realm of drug discovery more intricate, rigid small molecules exhibit higher potencies as drug leads and candidates. This is because molecules with three-dimensional features such as stereochemistry and bond ...
NARROW OPEN TUBULAR LIQUID CHROMATOGRAPHY: SEPARATION OPTIMIZATION AND COLUMN IMPROVEMENT
(2020-05-08)
The continuous progress of life sciences such as genome sequencing, proteomics and metabolomics has facilitated the development of effective tools to better analyze the large numbers of bio-samples with low quantities and ...
Single-probe Single Cell Mass Spectrometry Studies: Investigation of Cell Heterogeneity and Quantification of Intracellular Small Molecules
(2023-12-15)
Studying cell heterogeneity can provide a deeper understanding of biological activities, but corresponding studies cannot be performed using traditional bulk analysis methods. The development of diverse single cell bioanalysis ...
Elucidating the mechanisms of DNA cleavage by CRISPR effector proteins, Cas9 and Cas12a
(2021-05-14)
CRISPR-Cas systems are adaptive immune systems protecting bacteria and archaea against
intruding genetic elements. Of the different types, the signature nucleases of type II and type VA, Cas9 and Cas12a, are popular choices ...
Low-molecular-weight branched polyethylenimines: Multifunctional beta-lactam potentiators against resistant Gram-negative pathogens
(2022-05-13)
Antibiotic resistance is a simmering threat to the global public health system. Currently, it is estimated by the Centers for Disease Control and Prevention that at least 2.8 million people in the US get infected with ...
Development and application of high throughput hydrogen deuterium exchange mass spectrometry for characterizing protein interactions in complex biological samples
(2023-05-12)
Protein interactions (e.g., protein-protein interactions and protein-ligand interactions) play an important role in regulating the numerous biological processes that dictate cellular activity. The characterization of protein ...
Characterization of the protein-protein interactions of the type-II toxin-antitoxin system ParDE1 from Pseudomonas aeruginosa
(2023-05-12)
The emergence of multidrug-resistant bacteria has led to an ever-growing antibiotic resistance crisis. To combat this growing crisis, new strategies for controlling bacterial cell growth must be developed. An underdeveloped ...
Exploring cell heterogeneity: applications of single-probe single cell mass spectrometry for subpopulation analysis
(2023-12-15)
Mass spectrometry (MS) has become an indispensable tool for transformed metabolomics studies, whereas exploring single-cell metabolomic profiles remains a challenge due to limited techniques and suitable algorithms. This ...
Applications of Button Sample Holders for Mid-Infrared Spectroscopy Measurements
(2021-12-17)
Infrared (IR) spectroscopy is a rapid and non-destructive method for chemical analysis that is based on interactions between electromagnetic radiation and matter. Despite its widespread popularity in commercial and research ...
Development of Novel Material Design Strategies for High-Efficiency and Tunable Photoluminescence Properties
(2022-12-16)
New developments in the understanding of structural-optical property relationships of optoelectronic materials have led to rapid growth in energy-efficient solid-state lighting technologies. These improvements in the field ...