Browsing by Author "996bbb06-efb0-4368-9562-16d8ab98a0f4"
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Exogenously scavenged and endogenously synthesized heme are differentially utilized by Mycobacterium tuberculosis
Donegan, Rebecca K.; Fu, Yibo; Copeland, Jacqueline; Idga, Stanzin; Brown, Gabriel; Hale, Owen F.; Mitra, Avishek; Yang, Hui; Dailey, Harry A.; Niederweis, Michael; Jain, Paras; Reddi, Amit R. (American Society for Microbiology, 2022-10-26)Heme is both an essential cofactor and an abundant source of nutritional iron for the human pathogen Mycobacterium tuberculosis. While heme is required for M. tuberculosis survival and virulence, it is also potentially ... -
Heme and hemoglobin utilization by Mycobacterium tuberculosis
Mitra, Avishek; Ko, Ying-Hui; Cingolani, Gino; Niederweis, Michael (Springer Nature, 2019-09-18)Iron is essential for growth of Mycobacterium tuberculosis (Mtb), but most iron in the human body is stored in heme within hemoglobin. Here, we demonstrate that the substrate-binding protein DppA of the inner membrane Dpp ... -
Mycobacteria, metals, and the macrophage
Neyrolles, Olivier; Wolschendorf, Frank; Mitra, Avishek; Niederweis, Michael (Wiley, 2015-03)Mycobacterium tuberculosis is a facultative intracellular pathogen that thrives inside host macrophages. A key trait of M. tuberculosis is to exploit and manipulate metal cation trafficking inside infected macrophages to ... -
PPE surface proteins are required for heme utilization by Mycobacterium tuberculosis
Mitra, Avishek; Speer, Alexander; Lin, Kan; Ehrt, Sabine; Niederweis, Michael (American Society for Microbiology, 2017-03-08)Iron is essential for replication of Mycobacterium tuberculosis, but iron is efficiently sequestered in the human host during infection. Heme constitutes the largest iron reservoir in the human body and is utilized by many ... -
Protein complex from human milk enhances the activity of antibiotics and drugs against Mycobacterium tuberculosis.
Meikle, Virginia; Mossberg, Ann-Kristin; Mitra, Avishek; Hakansson, Anders P.; Niederweis, Michael (American Society for Microbiology, 2019-02)Mycobacterium tuberculosis, the causative agent of human tuberculosis (TB), has surpassed HIV/AIDS as the leading cause of death from a single infectious agent. The increasing occurrence of drug-resistant strains has become ... -
Role of the Mycobacterium tuberculosis ESX-4 secretion system in heme iron utilization and pore formation by PPE proteins
Sankey, November; Merrick, Haley; Singh, Padam; Rogers, Janet; Reddi, Amit; Hartson, Steven D.; Mitra, Avishek (American Society for Microbiology, 2023-02-07)Mycobacterium tuberculosis (Mtb) is transmitted through aerosols and primarily colonizes within the lung. The World Health Organization estimates that Mtb kills ~1.4 million people every year. A key aspect that makes Mtb ... -
Shiga toxin 2 overexpression in Escherichia coli O157:H7 strains associated with severe human disease
Neupane, Mahesh; Abu-Ali, Galeb S.; Mitra, Avishek; Lacher, David W.; Manning, Shannon D.; Riordan, James T. (Elsevier, 2011-12)Variation in disease severity among Escherichia coli O157:H7 infections may result from differential expression of Shiga toxin 2 (Stx2). Eleven strains belonging to four prominent phylogenetic clades, including clade 8 ... -
Sigma factor n, liaison to an ntrC and rpoS dependent regulatory pathway controlling acid resistance and the LEE in enterohemorrhagic Escherichia coli
Mitra, Avishek; Fay, Pamela A.; Morgan, Jason K.; Vendura, Khoury W.; Versaggi, Salvatore L.; Riordan, James T. (Public Library of Science (PLoS), 2012)Enterohemorrhagic Escherichia coli (EHEC) is dependent on acid resistance for gastric passage and low oral infectious dose, and the locus of enterocyte effacement (LEE) for intestinal colonization. Mutation of rpoN, encoding ... -
σᴺ-dependent control of acid resistance and the locus of enterocyte effacement in enterohemorrhagic Escherichia coli is activated by acetyl phosphate in a manner requiring flagellar regulator FlhDC and the σS antagonist FliZ
Mitra, Avishek; Fay, Pamela A.; Vendura, Khoury W.; Alla, Zimrisha; Carroll, Ronan K.; Shaw, Lindsey N.; Riordan, James T. (Wiley, 2014-08)In enterohemorrhagic Escherichia coli (EHEC), sigma factor N (σᴺ) regulates glutamate-dependent acid resistance (GDAR) and the locus of enterocyte effacement (LEE); discrete genetic systems that are required for transmission ...