The Advancement of Narrow Open Tubular Liquid Chromatography

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dc.contributor.advisorYang, Zhibo
dc.contributor.authorXiang, Piliang
dc.contributor.committeeMemberNanny, Mark
dc.contributor.committeeMemberShao, Yihan
dc.contributor.committeeMemberWu, Si
dc.date.accessioned2021-09-29T19:57:08Z
dc.date.available2021-09-29T19:57:08Z
dc.date.issued2021-12-17
dc.date.manuscript2021-09
dc.description.abstractOpen tubular columns are primarily used in gas chromatography, and they were regarded as the best choice to achieve high separation efficiency in gas chromatography. Substances diffuse much slower in liquids than in gases. An open tubular liquid chromatography column must have a small inner diameter to achieve high separation efficiency. We are one of the pioneers that explored narrow open tubular liquid chromatography with 2 μm inner diameter capillaries. Based on previous high efficiency separation of 11 fluorescently derivatized amino acids, we improved the column preparation and greatly enhanced the separation efficiency of the narrow open tubular column. This thesis focuses on optimizing the narrow open tubular column for high efficiency separation, high speed separation, high throughput separation and coupling it with mass spectrometer for single cell bottom-up proteomics.en_US
dc.identifier.urihttps://hdl.handle.net/11244/331000
dc.languageen_USen_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectOpen Tubular Liquid Chromatographyen_US
dc.subjectLiquid Chromatographyen_US
dc.subjectLC-MSen_US
dc.subjectFlow Injection Chromatographyen_US
dc.thesis.degreePh.D.en_US
dc.titleThe Advancement of Narrow Open Tubular Liquid Chromatographyen_US
ou.groupCollege of Arts and Sciences::Department of Chemistry and Biochemistryen_US
shareok.orcid0000-0002-7742-7083en_US

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