DESIGN AND SYNTHESIS OF NEW CLPP ACTIVATORS: TOWARDS THE DEVELOPMENT OF A COMPUTATIONALLY GUIDED APPROACH

dc.contributor.advisor	Duerfeldt, Adam S.
dc.contributor.author	Avila, Quentin P.
dc.contributor.committeeMember	Cichewicz, Robert
dc.contributor.committeeMember	De Sainte Claire, Pascal
dc.contributor.committeeMember	Glatzhofer, Daniel
dc.contributor.committeeMember	Ripoche, Isabelle
dc.date.accessioned	2016-12-01T15:37:52Z
dc.date.available	2016-12-01T15:37:52Z
dc.date.issued	2016-12
dc.date.manuscript	2016
dc.description.abstract	With the rise of antibiotic-resistant bacteria, there is an urgent need to develop antibacterials with new mechanisms of action. Because of its essential role in bacterial survival and the possibility to induce unselective substrate degradation via activation by small molecules, ClpP is an interesting target. Given the small number of chemotypes known to target ClpP ant the limited understanding of protein-ligand interactions involved in the binding of ClpP activators, we sought to develop a computational approach to provide insight into specific ligand-ClpP interactions and address some of the structure optimization issues in the field.	en_US
dc.identifier.uri	http://hdl.handle.net/11244/46949
dc.language	en_US	en_US
dc.subject	Medicinal chemistry, Organic chemisty, Computational chemistry, Synthesis	en_US
dc.thesis.degree	Master of Science	en_US
dc.title	DESIGN AND SYNTHESIS OF NEW CLPP ACTIVATORS: TOWARDS THE DEVELOPMENT OF A COMPUTATIONALLY GUIDED APPROACH	en_US
ou.group	College of Arts and Sciences::Department of Chemistry and Biochemistry	en_US