Design and fabrication of a 3D printed hybrid implant for temporomandibular joint regeneration

Rassi, Ali

Design and fabrication of a 3D printed hybrid implant for temporomandibular joint regeneration

dc.contributor.advisor	Huebner, Pedro
dc.contributor.author	Rassi, Ali
dc.contributor.committeeMember	Detamore, Michael
dc.contributor.committeeMember	Raman, Shivakumar
dc.date.accessioned	2021-08-05T15:41:44Z
dc.date.available	2021-08-05T15:41:44Z
dc.date.issued	2021
dc.date.manuscript	2021-08-04
dc.description.abstract	Patients suffering from temporomandibular joint (TMJ) disorders have difficulties performing trivial activities such as chewing, yawning, and even laughing. In severe cases, the pain is unbearable and clinical care is required. When non- or minimally invasive treatments fall short to resolve the problem, total joint replacements with permanent alloplastic implants are recommended by surgeons. However, recent advances in tissue engineering research have highlighted the potential of using bioengineered implants over their traditional alloplastic counterparts. In this study, the design and fabrication processes of a patient-fitted hybrid biodegradable TMJ implant are studied, focusing on the mitigation of complications and limitations of conventional implants. The proposed implant design incorporates both bone and cartilage components of the TMJ in a single heterogeneous unit and is affixed to the ramus of the mandible. By including microporous features in the condylar head of the implant, we seek to increase the rate of cell infiltration via capillary forces in the scaffolding structures and reinforce the bond between the bone and the cartilage regions so as to obtain a faster and more effective regeneration of the targeted tissues. Statistical design of experiments is adopted to identify the best-performing features that are ultimately implemented into the final design of the full-size TMJ implant. Lastly, techniques for incorporating these microarchitectural features and improving the fabrication process are presented and discussed.	en_US
dc.identifier.uri	https://hdl.handle.net/11244/330212
dc.language	en_US	en_US
dc.subject	3D printing	en_US
dc.subject	tissue engineering	en_US
dc.subject	temporomandibular joint	en_US
dc.subject	hybrid implant	en_US
dc.thesis.degree	Master of Science	en_US
dc.title	Design and fabrication of a 3D printed hybrid implant for temporomandibular joint regeneration	en_US
ou.group	Gallogly College of Engineering::School of Industrial and Systems Engineering	en_US