Effect of Dietary Source and Concentrations of Copper, Manganese, and Zinc on Growth Performance and Immune Response of Nursery Pigs.
Abstract
Two experiments were conducted to evaluate dietary source and concentrations of copper, manganese, and zinc on growth performance and the immune response of nursery pigs. Experiment 1 and 2 evaluated two sources of copper, manganese, and zinc: sulfate and chloride. Both sources were then evaluated in two dietary concentrations. To study the acute immune response, all pigs in both experiments were subjected to acute immune challenge by single intraperitoneal injection of lipopolysaccharide (LPS). Additionally, pigs from experiment 2 were subjected to multiple intramuscular injections of LPS to evaluate the chronic immune response. The data from experiment 1 and 2 relative to growth performance and acute immune challenge were combined for statistical analysis. Overall, BW, ADG, ADFI, and G:F ratio were not different among dietary treatment groups. Following the acute immune challenge, pigs fed both dietary concentrations of chlorides produced lower concentrations of TNF-? and IL-1?. A concentration effect was also observed, with higher dietary concentrations of both sources producing less TNF-? and IL-1?. Total-SOD activity was not affected by dietary treatments following the acute immune challenge. During the multiple LPS injections, growth performance was negatively affected; however, no differences were observed among dietary treatment groups. Numerically, TNF-? concentration was lower and total-SOD activity was greater in both dietary concentrations of chlorides. IL-1? was not affected by dietary treatment group during the chronic immune challenge. In conclusion, chloride sources are able to alleviate the acute immune response by decreasing the proinflammatory cytokine production regardless of the dietary concentration, suggesting a higher bioavailability over sulfate sources. Besides that, high dietary concentration of copper, manganese, and zinc showed more promising results, indicating that the immune response may have a greater requirement than that needed for growth. Following a chronic immune challenge, chloride sources showed a numerical advantage over sulfates, suggesting less stimulation of the inflammatory response.
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- OSU Theses [15752]