Patients suffering from temporomandibular joint (TMJ) disorders have difficulties performing trivial activities such as chewing, yawning, and even laughing. In severe cases, the pain is unbearable and clinical care is required. When non- or minimally invasive treatments fall short to resolve the problem, total joint replacements with permanent alloplastic implants are recommended by surgeons. However, recent advances in tissue engineering research have highlighted the potential of using bioengineered implants over their traditional alloplastic counterparts. In this study, the design and fabrication processes of a patient-fitted hybrid biodegradable TMJ implant are studied, focusing on the mitigation of complications and limitations of conventional implants. The proposed implant design incorporates both bone and cartilage components of the TMJ in a single heterogeneous unit and is affixed to the ramus of the mandible. By including microporous features in the condylar head of the implant, we seek to increase the rate of cell infiltration via capillary forces in the scaffolding structures and reinforce the bond between the bone and the cartilage regions so as to obtain a faster and more effective regeneration of the targeted tissues. Statistical design of experiments is adopted to identify the best-performing features that are ultimately implemented into the final design of the full-size TMJ implant. Lastly, techniques for incorporating these microarchitectural features and improving the fabrication process are presented and discussed.