This research project involved the development of a fully customizable, user-defined hardware-software suite for automated signal routing with function expandability. Because of the above-mentioned characteristics, the project was called Programmable Integrated Switch Matrix (PrISM). This intelligent switching system can be customized and employed in any industry where there is a need for programmable, timed, and/or simultaneous routing of analog or digital signals between devices. Potential applications of these automated switching systems include, but are not limited to: demarcation points, test floors, redundant backup systems, remote maintenance, etc. A suitable test bed for PrISM was found in a collaboration with the Federal Aviation Administration (FAA) Oklahoma Communications Engineering Team (OKCET) Laboratory and has found an immediate potential application as a large-scale switching system. The fundamental hardware unit for this system is the National Instruments (NI) PXI chassis with a NI SwitchBlock populated with matrix relay cards. The chassis can be deployed in any location, contributing to the robust nature of the design. The advantage of using an integrated NI system is its modularity; the hardware can be easily tailored to the specific needs of each end user. Expansion and customization is accomplished with the addition of a wide spectrum of matrix relay cards. Matrix cards are available with a varying number of relays or switching points. The proposed system is controlled and automated by a customized virtual instrument (VI) application software that was developed using NI LabVIEW software environment and can be integrated with the PXI or function as an executable on a standalone desktop computer.