Role of ppGpp in regulating global gene expression in Escherichia coli.

dc.contributor.advisor	Conway, Tyrrell
dc.creator	Traxler, Matthew F.
dc.date.accessioned	2019-05-01T17:24:31Z
dc.date.available	2019-05-01T17:24:31Z
dc.date.issued	2009
dc.identifier	9912879102042
dc.identifier.uri	https://hdl.handle.net/11244/319460
dc.description.abstract	Bacteria grow when nutrient availability supports basic biochemical requirements and remain in stationary phase when basic needs go unmet. This deceptively simple phenomenon requires the orchestrated expression of thousands of genes. Free-living bacteria use a nucleotide second messenger, ppGpp, as a physiological signal and effector to appropriately coordinate global gene expression according to the nutritional quality of the environment. Over the last four decades, expression of many individual genes has been tied to the absence or presence of ppGpp, yet the full scope of gene expression mediated by ppGpp remained undefined. This dissertation defines the role of ppGpp in regulating global gene expression in a model bacterium, Escherichia coli.
dc.format.extent	205 pages
dc.format.medium	application.pdf
dc.language	en_US
dc.relation.requires	Adobe Acrobat Reader
dc.subject	Genetic regulation
dc.subject	Bacterial genomes
dc.subject	Escherichia coli
dc.title	Role of ppGpp in regulating global gene expression in Escherichia coli.
dc.type	text
dc.type	document
dc.thesis.degree	Ph.D.
ou.group	College of Arts and Sciences::Department of Microbiology and Plant Biology

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