dc.contributor.author | Kim, Helen | |
dc.contributor.author | Hutter, Carolyn M. | |
dc.contributor.author | Monks, Stephanie A. | |
dc.contributor.author | Edwards, Karen L. | |
dc.date.accessioned | 2018-11-09T21:10:47Z | |
dc.date.available | 2018-11-09T21:10:47Z | |
dc.date.issued | 2005-12-30 | |
dc.identifier | oksd_kim_comparisonofsin_2005 | |
dc.identifier.citation | Kim, H., Hutter, C. M., Monks, S. A., & Edwards, K. L. (2005). Comparison of single-nucleotide polymorphisms and microsatellites in detecting quantitative trait loci for alcoholism: The Collaborative Study on the Genetics of Alcoholism. BMC Genetics, 6(Suppl 1), Article S5. https://doi.org/10.1186/1471-2156-6-S1-S5 | |
dc.identifier.uri | https://hdl.handle.net/11244/302054 | |
dc.description.abstract | Background: The feasibility of effectively analyzing high-density single nucleotide polymorphism (SNP) maps in whole genome scans of complex traits is not known. The purpose of this study was to compare variance components linkage results using different density marker maps in data from the Collaborative Study on the Genetics of Alcoholism (COGA). Marker maps having an average spacing of 10 cM (microsatellite), 0.78 cM (SNP1), and 0.31 cM (SNP2) were used to identify quantitative trait loci (QTLs) affecting maximum number of alcoholic drinks consumed in a 24-hour period (lnmaxalc). | |
dc.description.abstract | Results: Heritability of lnmaxalc was estimated to be 15%. Multipoint variance components linkage analysis revealed similar linkage patterns among the three marker panels, with the SNP maps consistently yielding higher LOD scores. Robust LOD scores > 1.0 were observed on chromosomes 1 and 13 for all three marker maps. Additional LODs > 1.0 were observed on chromosome 4 with both SNP maps and on chromosomes 18 and 21 with the SNP2 map. Peak LOD scores for lnmaxalc were observed on chromosome 1, although none reached genome-wide statistical significance. Quantile-quantile plots revealed that the multipoint distribution of SNP results appeared to fit the asymptotic null distribution better than the twopoint results. | |
dc.description.abstract | Conclusion: In conclusion, variance-components linkage analysis using high-density SNP maps provided higher LOD scores compared with the standard microsatellite map, similar to studies using nonparametric linkage methods. Widespread application of SNP maps will depend on further improvements in the computational methods implemented in current software packages. | |
dc.format | application/pdf | |
dc.language | en_US | |
dc.publisher | BioMed Central | |
dc.rights | This material has been previously published. In the Oklahoma State University Library's institutional repository this version is made available through the open access principles and the terms of agreement/consent between the author(s) and the publisher. The permission policy on the use, reproduction or distribution of the material falls under fair use for educational, scholarship, and research purposes. Contact Digital Resources and Discovery Services at lib-dls@okstate.edu or 405-744-9161 for further information. | |
dc.title | Comparison of single-nucleotide polymorphisms and microsatellites in detecting quantitative trait loci for alcoholism: The Collaborative Study on the Genetics of Alcoholism | |
osu.filename | oksd_kim_comparisonofsin_2005.pdf | |
dc.description.peerreview | Peer reviewed | |
dc.identifier.doi | 10.1186/1471-2156-6-S1-S5 | |
dc.description.department | Statistics | |
dc.type.genre | Article | |
dc.type.material | Text | |
dc.subject.keywords | asymptotic null distribution | |
dc.subject.keywords | average marker spacing | |
dc.subject.keywords | variance component linkage analysis | |
dc.subject.keywords | single nucleotide polymorphism result | |
dc.subject.keywords | multipoint IBDs | |