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New Mycobacterium avium antifolate shows synergistic effect when used in combination with dihydropteroate synthase inhibitors

dc.contributor.authorSuling, W. J.
dc.contributor.authorSeitz, L. E.
dc.contributor.authorReynolds, R. C.
dc.contributor.authorBarrow, W. W.
dc.date.accessioned2018-08-15T12:44:22Z
dc.date.available2018-08-15T12:44:22Z
dc.date.issued2005-11
dc.identifieroksd_suling_newmycobacteriu_2005
dc.identifier.citationSuling, W. J., Seitz, L. E., Reynolds, R. C., & Barrow, W. W. (2005). New Mycobacterium avium antifolate shows synergistic effect when used in combination with dihydropteroate synthase inhibitors. Antimicrobial Agents and Chemotherapy, 49(11), 4801-4803. https://doi.org/10.1128/AAC.49.11.4801-4803.2005
dc.identifier.urihttps://hdl.handle.net/11244/301414
dc.description.abstractMycobacterium avium complex (MAC) is resistant to trimethoprim, an inhibitor of bacterial dihydrofolate reductase (DHFR). A previously identified selective inhibitor of MAC DHFR, SRI-8858, was shown to have synergistic activity in combination with dapsone and sulfamethoxazole, two drugs that inhibit bacterial dihydropteroate synthase.
dc.formatapplication/pdf
dc.languageen_US
dc.publisherAmerican Society for Microbiology
dc.rightsThis material has been previously published. In the Oklahoma State University Library's institutional repository this version is made available through the open access principles and the terms of agreement/consent between the author(s) and the publisher. The permission policy on the use, reproduction or distribution of the material falls under fair use for educational, scholarship, and research purposes. Contact Digital Resources and Discovery Services at lib-dls@okstate.edu or 405-744-9161 for further information.
dc.titleNew Mycobacterium avium antifolate shows synergistic effect when used in combination with dihydropteroate synthase inhibitors
osu.filenameoksd_suling_newmycobacteriu_2005.pdf
dc.description.peerreviewPeer reviewed
dc.identifier.doi10.1128/AAC.49.11.4801-4803.2005
dc.description.departmentVeterinary Health Sciences
dc.type.genreArticle
dc.type.materialText
dc.subject.keywordsdrug combination
dc.subject.keywordsdrug interaction
dc.subject.keywordssynergism
dc.subject.keywordsenzyme
dc.subject.keywordstransferases
dc.subject.keywordsbacteria
dc.subject.keywordsactinomycetes
dc.subject.keywordsmycobacteriales
dc.subject.keywordsmycobacteriaceae


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