New Mycobacterium avium antifolate shows synergistic effect when used in combination with dihydropteroate synthase inhibitors
Date
2005-11Author
Suling, W. J.
Seitz, L. E.
Reynolds, R. C.
Barrow, W. W.
Metadata
Show full item recordAbstract
Mycobacterium avium complex (MAC) is resistant to trimethoprim, an inhibitor of bacterial dihydrofolate reductase (DHFR). A previously identified selective inhibitor of MAC DHFR, SRI-8858, was shown to have synergistic activity in combination with dapsone and sulfamethoxazole, two drugs that inhibit bacterial dihydropteroate synthase.
Citation
Suling, W. J., Seitz, L. E., Reynolds, R. C., & Barrow, W. W. (2005). New Mycobacterium avium antifolate shows synergistic effect when used in combination with dihydropteroate synthase inhibitors. Antimicrobial Agents and Chemotherapy, 49(11), 4801-4803. https://doi.org/10.1128/AAC.49.11.4801-4803.2005