| dc.contributor.author | Chen, C. L. | |
| dc.contributor.author | Roder, J. D. | |
| dc.contributor.author | Sangiah, S. | |
| dc.contributor.author | Chen, H. | |
| dc.contributor.author | Berlin, K. D. | |
| dc.contributor.author | Garrison, G. L. | |
| dc.contributor.author | Scherlag, B. J. | |
| dc.contributor.author | Lazzara, R. | |
| dc.contributor.author | Patterson, E. | |
| dc.date.accessioned | 2015-10-16T20:47:44Z | |
| dc.date.available | 2015-10-16T20:47:44Z | |
| dc.date.issued | 1993-06 | |
| dc.identifier | okds_Berlin_AS_1993-06 | |
| dc.identifier.citation | Chen, C. L., Roder, J. D., Sangiah, S., Chen, H., Berlin, K. D., Garrison, G. L., ... Patterson, E. (1993). High-performance liquid chromatographic determination of SAZ-VII-22, a novel antiarrhythmic agent, in dog plasma and urine. Analytical Sciences, 9(3), 429-431. https://doi.org/10.2116/analsci.9.429 | |
| dc.identifier.uri | https://hdl.handle.net/11244/19777 | |
| dc.description.abstract | SAZ-VII-22 [3-(4-chlorobenzoyl)-7-isopropyl-3,7-diazabicyclo[3.3.1]nonane, (A)](Fig. 1) has been shown to have effective antiarrhythmic properties with modest class-III antiarrhythmic activity.1,2 The basis of some electrophysiological effects of the antiarrhythmic properties of A could possibly be due to its inhibitory effects on myocardial Na+, K+-ATPase and Mg2+-ATPase activities.3 | |
| dc.description.abstract | There are no analytical methods currently available for determining the amount of A in biological fluids. This paper describes a rapid, selective HPLC technique for the determination of this compound in biological fluids, including plasma and urine, which was successfully used to characterize preliminary pharmacokinetic profiles of A in a dog. | |
| dc.format | application/pdf | |
| dc.language | en_US | |
| dc.publisher | Japan Society for Analytical Chemistry | |
| dc.rights | This material has been previously published. In the Oklahoma State University Library's institutional repository this version is made available through the open access principles and the terms of agreement/consent between the author(s) and the publisher. The permission policy on the use, reproduction or distribution of the material falls under fair use for educational, scholarship, and research purposes. Contact Digital Resources and Discovery Services at lib-dls@okstate.edu or 405-744-9161 for further information. | |
| dc.title | High-performance liquid chromatographic determination of SAZ-VII-22, a novel antiarrhythmic agent, in dog plasma and urine | |
| osu.filename | okds_Berlin_AS_1993-06.pdf | |
| dc.description.peerreview | Peer reviewed | |
| dc.identifier.doi | 10.2116/analsci.9.429 | |
| dc.description.department | Physiological Sciences | |
| dc.description.department | Chemistry | |
| dc.type.genre | Article | |
| dc.type.material | Text | |
| dc.subject.keywords | high-performance liquid chromatography | |
| dc.subject.keywords | antiarrhythmic | |
| dc.subject.keywords | pharmacokinetics | |
| dc.subject.keywords | nonane | |
