High-performance liquid chromatographic determination of SAZ-VII-22, a novel antiarrhythmic agent, in dog plasma and urine
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Date
1993-06Author
Chen, C. L.
Roder, J. D.
Sangiah, S.
Chen, H.
Berlin, K. D.
Garrison, G. L.
Scherlag, B. J.
Lazzara, R.
Patterson, E.
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SAZ-VII-22 [3-(4-chlorobenzoyl)-7-isopropyl-3,7-diazabicyclo[3.3.1]nonane, (A)](Fig. 1) has been shown to have effective antiarrhythmic properties with modest class-III antiarrhythmic activity.1,2 The basis of some electrophysiological effects of the antiarrhythmic properties of A could possibly be due to its inhibitory effects on myocardial Na+, K+-ATPase and Mg2+-ATPase activities.3 There are no analytical methods currently available for determining the amount of A in biological fluids. This paper describes a rapid, selective HPLC technique for the determination of this compound in biological fluids, including plasma and urine, which was successfully used to characterize preliminary pharmacokinetic profiles of A in a dog.
Citation
Chen, C. L., Roder, J. D., Sangiah, S., Chen, H., Berlin, K. D., Garrison, G. L., ... Patterson, E. (1993). High-performance liquid chromatographic determination of SAZ-VII-22, a novel antiarrhythmic agent, in dog plasma and urine. Analytical Sciences, 9(3), 429-431. https://doi.org/10.2116/analsci.9.429