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Bacterial community structure and diversity in a century-old manure-treated agroecosystem
(American Society for Microbiology, 2004-10)
Changes in soil microbial community structure and diversity may reflect environmental impact. We examined 16S rRNA gene fingerprints of bacterial communities in six agroecosystems by PCR amplification and denaturing gradient ...
Crystal structure of Bacillus anthracis dihydrofolate reductase with the dihydrophthalazine-based trimethoprim derivative RAB1 provides a structural explanation of potency and selectivity
(American Society for Microbiology, 2009-07)
Bacillus anthracis possesses an innate resistance to the antibiotic trimethoprim due to poor binding to dihydrofolate reductase (DHFR); currently, there are no commercial antibacterials that target this enzyme in B. ...
In vitro efficacy of new antifolates against trimethoprim-resistant Bacillus anthracis
(American Society for Microbiology, 2007-12)
Bacillus anthracis is innately resistant to trimethoprim (TMP), a synthetic antifolate that selectively inhibits several bacterial dihydrofolate reductases (DHFRs) but not human DHFR. Previously, we were able to confirm ...
Novelty and uniqueness patterns of rare members of the soil biosphere
(American Society for Microbiology, 2008-09)
Soil bacterial communities typically exhibit a distribution pattern in which most bacterial species are present in low abundance. Due to the relatively small size of most culture-independent sequencing surveys, a detailed ...
Genomic comparison of plant pathogenic and nonpathogenic Serratia marcescens strains by suppressive subtractive hybridization
(American Society for Microbiology, 2005-12)
Cucurbit yellow vine disease (CYVD) is caused by disease-associated Serratia marcescens strains that have phenotypes significantly different from those of nonphytopathogenic strains. To identify the genetic differences ...
Microbial community structure in petroleum-contaminated sediments corresponds to geophysical signatures
(American Society for Microbiology, 2007-05)
The interdependence between geoelectrical signatures at underground petroleum plumes and the structures of subsurface microbial communities was investigated. For sediments contaminated with light non-aqueous-phase liquids, ...
Microplate fluorescence assay for measurement of the ability of strains of Listeria monocytogenes from meat and meat-processing plants to adhere to abiotic surfaces
(American Society for Microbiology, 2007-08)
Listeria monocytogenes is a significant food-borne pathogen that is capable of adhering to and producing biofilms on processing equipment, making it difficult to eliminate from meat-processing environments and allowing ...
Prevalence of Escherichia coli O157 in cattle feeds in Midwestern feedlots
(American Society for Microbiology, 2003-09)
Comparisons of enrichment methods (with or without antibiotics and with or without a preenrichment step) using gram-negative (GN) broth or tryptic soy broth (TSB) were conducted with feeds inoculated with Escherichia coli ...
New Mycobacterium avium antifolate shows synergistic effect when used in combination with dihydropteroate synthase inhibitors
(American Society for Microbiology, 2005-11)
Mycobacterium avium complex (MAC) is resistant to trimethoprim, an inhibitor of bacterial dihydrofolate reductase (DHFR). A previously identified selective inhibitor of MAC DHFR, SRI-8858, was shown to have synergistic ...
Characterization of Anaplasma marginale isolated from North American bison
(American Society for Microbiology, 2003-08)
Anaplasma marginale (Rickettsiales: Anaplasmataceae), a tick-borne pathogen of cattle, is endemic in tropical and subtropical regions of the world. Although serologic tests have identified American bison, Bison bison, as ...