Browsing OSU - Faculty and Staff Publications by Subject "Virulence"

Now showing items 1-3 of 3

    • Mycobacteria, metals, and the macrophage 

      Neyrolles, Olivier; Wolschendorf, Frank; Mitra, Avishek; Niederweis, Michael (Wiley, 2015-03)
      Mycobacterium tuberculosis is a facultative intracellular pathogen that thrives inside host macrophages. A key trait of M. tuberculosis is to exploit and manipulate metal cation trafficking inside infected macrophages to ...

    • PPE surface proteins are required for heme utilization by Mycobacterium tuberculosis 

      Mitra, Avishek; Speer, Alexander; Lin, Kan; Ehrt, Sabine; Niederweis, Michael (American Society for Microbiology, 2017-03-08)
      Iron is essential for replication of Mycobacterium tuberculosis, but iron is efficiently sequestered in the human host during infection. Heme constitutes the largest iron reservoir in the human body and is utilized by many ...

    • Shiga toxin 2 overexpression in Escherichia coli O157:H7 strains associated with severe human disease 

      Neupane, Mahesh; Abu-Ali, Galeb S.; Mitra, Avishek; Lacher, David W.; Manning, Shannon D.; Riordan, James T. (Elsevier, 2011-12)
      Variation in disease severity among Escherichia coli O157:H7 infections may result from differential expression of Shiga toxin 2 (Stx2). Eleven strains belonging to four prominent phylogenetic clades, including clade 8 ...