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New Mycobacterium avium antifolate shows synergistic effect when used in combination with dihydropteroate synthase inhibitors
(American Society for Microbiology, 2005-11)
Mycobacterium avium complex (MAC) is resistant to trimethoprim, an inhibitor of bacterial dihydrofolate reductase (DHFR). A previously identified selective inhibitor of MAC DHFR, SRI-8858, was shown to have synergistic ...