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CONSTANT-pH MOLECULAR DYNAMICS SIMULATIONS: DEVELOPMENT AND APPLICATIONS
(2012)
Constant-pH molecular dynamics has recently emerged as a useful technique for studying the microscopic details underlying pH dependent properties of proteins. We further develop continuous constant-pH molecular dynamics ...
Cascade Reactions to Access Bioactive Scaffolds
(2020-07-16)
In the recent decade there has been a shift in drug development to favor planar, aromatic small molecules with easy synthetic access, despite centuries of research in bioactive natural products, which are often highly ...
Characterization of the second-half reaction of O-acetylserine sulfhydrylase-A and the reaction of O-acetylserine sulfhydrylase-B from Salmonella typhimurium.
(2004)
The O-acetylserine sulfhydrylase-B (OASS-B) was recently overexpressed and purified to electrophoretic homogeneity (>98% pure). Both the quantity and purity of the enzyme permit more kinetic and structurally based studies ...
Mining Microbial Communities: Exploring Symbiotic Bacteria as a Source of New Natural Products
(2013)
As ubiquitous inhabitants of Earth, bacteria represent a diverse resource in the search for new natural products. In order for the field of natural products to progress, new and exciting sources of biodiversity must be ...
Applications of Hyphenated Analytical Techniques in Pharmaceutical Industry
(2011)
Analytical chemistry plays a critical role in pharmaceutical research and development. A typical analysis includes separating and identifying active pharmaceutical ingredients and impurities, determining the quantity of ...
STUDIES OF THE USE OF THE [2.2]PARACYCLOPHANE MOIETY TO MEDIATE INTERACTION BETWEEN METAL CENTERS AND ELECTROPOLYMERIZATION OF 2,2’-BITHIOPHENE IN MICELLAR MEDIA
(2013)
Organometallic polymers have been identified as a class of materials useful in various advanced applications due to their promising electrical, magnetic, optical and catalytic properties. Such properties depend on the ...
Sequence and analysis of approximately 0.5 mega-basepair of the DiGeorge Syndrome Critical Region in human chromosome 22 band q11 and a syntenic mouse BAC.
(1997)
From the data collected, part of the genomic sequence of the human clathrin heavy chain like gene (CLTCL), entire genomic sequence of the human homolog of yeast repressors of histone gene transcription HIR1 and HIR2 (HIRA), ...
Bioactive Molecules Detection and Identification in Complex Biological Systems through Activity-Based Metabolomics and Proteomics
(2020-07)
The detection and identification of bioactive molecules (e.g. therapeutic small-molecule lead compounds, functional proteins) from complex mixtures is often a critical step in various biochemical and biomedical research ...
Synthesis of nitrogen heterocycles via transition metal catalyzed reductive cyclizations of nitroaromatics.
(2003)
This research focuses on applying a catalyst system discovered in this laboratory, for the intermolecular allylic amination of alkenes with nitrobenzenes, to the synthesis of nitrogen heterocycles via an intramolecular ...
Study of Metal-Enhanced Fluorescence of Dye-Doped Silica Nanoparticles
(2012)
Enhancement of molecular fluorescence is of great interest due to the widespread popularity of fluorescence-based detection techniques available today. Although fluorescence-based detection is considered to be more sensitive ...