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Now showing items 21-30 of 104
MEASURING RATE CONSTANTS FOR THE REACTION OF HYPOCHLOROUS ACID AND BIOLOGICALLY RELEVANT MOLECULES
(2012)
Hypochlorous acid (HOCl) is a neutrophil-derived oxidant that is used to kill invading pathogens. Since HOCl reacts indiscriminately with biological molecules, such as amino acids, excess or misplaced production of HOCl ...
Effects of Insecticides on Postmortem Interval: Implications on Forensic Investigations
(2011)
Postmortem interval (PMI) is the length of time that occurs between death of a person and the subsequent discovery of the body. PMI can be determined in a variety of ways depending on how long the body has been exposed ...
Design and Synthesis of OSW-1 Analogs and Other Bioactive Small Molecules for Potential Therapeutic Applications
(2018)
OSW-1 is a cholestane glycoside natural product with potent anti-proliferative activity, broad spectrum anti-viral activity, and a novel mechanism of action. The OSW-1’s cellular targets are oxysterol-binding protein (OSBP) ...
Filamentous Biological Macromolecules Based Nanostructures and Their Applications
(2010)
In nanoscience, one promising strategy for achieving precise placements of nanomaterials and specific recognitions between individual build blocks is to use self-ordered templates to arrange them into designed pattern. ...
NATURAL PRODUCTS AS A SOURCE OF NEW THERAPIES FOR NEURODEGENERATIVE DISEASE AND EFFORTS TOWARD THE DEVELOPMENT OF A METABOLOMICS-BASED DRUG DISCOVERY PLATFORM
(2010)
Natural products have traditionally played an important role in drug discovery research. They have been particularly important in the search for therapies for neurodegenerative diseases. Although there are numerous forms ...
Role of ATP binding and hydrolysis in assembly of MacAB-TolC macrolide transporter
(2013)
In Gram-negative bacteria, intrinsic antibiotic resistance is provided by three component efflux transporters. In Escherichia coli, MacAB-TolC is the first experimentally described ATP-driven tripartite efflux pump responsible ...
BIONANOFIBER-BASED NANOSTRUCTURE FABRICATION AND APPLICATIONS
(2017-12)
Among various strategies for the synthesis and assembly of nano-scaled structures, bio-templating is an efficient method due to the unique physical and chemical properties of the template bionanomaterials, thus has experienced ...
Chemical Modeling of Unstable Intermediates in Heme-mediated NOx Biology
(2017-05-12)
This dissertation describes the preparation, characterization, and reactivity of several critical unstable intermediates of relevance to the global N-cycle. Their spectroscopic signatures and chemical reactivities were ...
Imitating Nature: The Effects of Asymmetry and Strain on Copper and Iron Complexes with Schiff Base Ligands
(2013)
Metalloenzymes are incredibly complex "machines" which catalyze reactions essential for life. Metal ions are found in more than half of all known proteins; particularly, copper and iron are abundant in active sites performing ...
PROBING THE MECHANISM OF SACCHAROPINE DEHYDROGENASE FROM Saccharomyces cerevisiae USING SITE-DIRECTED MUTAGENESIS
(2010)
Saccharopine dehydrogenase (SDH) catalyses the NAD-dependent oxidative deamination of saccharopine to give L-lysine and alpha-ketoglutarate. There are a number of conserved hydrophilic, ionizable residues in the active ...