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Filamentous Biological Macromolecules Based Nanostructures and Their Applications
(2010)
In nanoscience, one promising strategy for achieving precise placements of nanomaterials and specific recognitions between individual build blocks is to use self-ordered templates to arrange them into designed pattern. ...
A study of the interactions of nitric oxide and nitric oxide containing molecules with heme proteins.
(2006)
The interactions of nitric oxide (NO), nitrite and organic nitroso compounds with heme proteins are biologically relevant. The formation of adducts between these NO-containing species and myoglobin (Mb) has served as a ...
Chemical Genetics and Molecular Pharmacology of the Oxysterol-Binding Proteins
(2020-07)
Oxysterol-binding protein (OSBP) and the OSBP-related proteins (ORPs) comprise a family of lipid-binding proteins organized into 6 subfamilies in humans. ORP subfamily 1 consists of OSBP and its closest homolog, ORP4. OSBP ...
NATURAL PRODUCTS AS A SOURCE OF NEW THERAPIES FOR NEURODEGENERATIVE DISEASE AND EFFORTS TOWARD THE DEVELOPMENT OF A METABOLOMICS-BASED DRUG DISCOVERY PLATFORM
(2010)
Natural products have traditionally played an important role in drug discovery research. They have been particularly important in the search for therapies for neurodegenerative diseases. Although there are numerous forms ...
Role of ATP binding and hydrolysis in assembly of MacAB-TolC macrolide transporter
(2013)
In Gram-negative bacteria, intrinsic antibiotic resistance is provided by three component efflux transporters. In Escherichia coli, MacAB-TolC is the first experimentally described ATP-driven tripartite efflux pump responsible ...
BIONANOFIBER-BASED NANOSTRUCTURE FABRICATION AND APPLICATIONS
(2017-12)
Among various strategies for the synthesis and assembly of nano-scaled structures, bio-templating is an efficient method due to the unique physical and chemical properties of the template bionanomaterials, thus has experienced ...
Studies of the complexation reactions of polyether ionophore antibiotics nigericin and salinomycin with lead(II), zinc, calcium, magnesium, sodium and potassium cations.
(2005)
CD studies in 80% methanol-water indicate that Pb2+ forms 1:1 complexes almost quantitatively with monensin, nigericin, narasin, maduramicin, and salinomycin. UV-Vis titrations in 80% methanol-water showed the same result ...
Harnessing metal carbenoids to assemble spirocycles and glycans
(2022-08-04)
Within the realm of drug discovery more intricate, rigid small molecules exhibit higher potencies as drug leads and candidates. This is because molecules with three-dimensional features such as stereochemistry and bond ...
Vibrational spectroscopy of phosphate-based electrodes for lithium rechargeable batteries.
(2006)
The favorable energy densities and cycling performances attainable from lithium rechargeable batteries has prompted aggressive research in this field for over 30 years. In particular, phosphate-based electrodes receive ...
Sequence and analysis of Actinobacillus actinomycetemcomitans.
(2002)
A. actinomycetemcomitans is a Gram negative coccobacillus, facultative anaerobe that is implicated in the persistence of peridontitis, the destruction of the gum tissues and loss of teeth (Fives-Taylor et al, 1999). In an ...