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Now showing items 51-60 of 104
MECHANISTIC AND STRUCTURAL STUDIES OF SACCHAROPINE DEHYDROGENASE FROM SACCHAROMYCES CEREVISIAE
(2010)
Lysine is an essential amino acid in mammals including humans. The α-aminoadipate (AAA) pathway for lysine biosynthesis is unique to fungal organisms and enzymes of this pathway are of interest as potential targets ...
REACTIONS OF NITRIC OXIDE, NITROSOALKANES WITH GROUP 8 & 9 METALLOPORPHYRINS AND HEME PROTEINS
(2015-08)
This dissertation describes the interactions of nitric oxide (NO) and C-nitrosoalkanes (RNO) with group 8 and 9 metalloporphyrins and heme proteins. The goal of this research is to provide new information on the coordination ...
A COMPUTATIONAL APPROACH FOR ACCESSING PHOSPHORYLATED RESPONSE REGULATOR CONFORMATIONS AND SIGNALING COMPLEXES INVOLVING THE FUNGAL PHOSPHORELAY PROTEIN YPD1
(2016-08)
Two-component signaling is the primary means by which bacteria, archaea and certain
eukaryotes sense and respond to their environments. Signal transfer proceeds through
sequential His-to-Asp phosphorylation of upstream ...
Mechanism and Interactions of Inner and Outer Membrane Components of RND Efflux Pumps
(2016-08)
Since the discovery of antibiotics, an ongoing race commenced between society’s ability to develop drugs and resistant bacteria. The combat has led to many drug discoveries, but it has also led to different mechanisms of ...
DESIGN, SYNTHESIS, AND APPLICATION OF DUAL FUNCTIONING BODIPY PHOTOSENSITIZERS: A THERANOSTIC PHOTODYNAMIC APPROACH FOR CANCER THERAPY
(2015-05)
Development of concomitant photodynamic therapy (PDT) and photosensitizer fluorescence detection (PFD), termed theranostics, is of primary interest as combining the two modalities stands to offer a more personalized cost ...
The Nature of Water in Bacterial Spores, Sporicidal Activity of Chlorine Dioxide, and Cryoprotectant Properties of Poly(adenylic) Acid
(2013)
Water is the fundamental chemical molecule of life, and the nature of how water interacts with living organisms and how living organisms can maintain liquid water for metabolic function below freezing (cryoprotection) is ...
ACTIVATION OF FUNGAL SILENT BIOSYTHETIC PATHWAYS BY EPIGENETIC MODIFICATION
(2011)
Natural products have played an important role as drug leads for different diseases. They provide unique structural cores with diverse biological activities. Because of the overuse of antibiotics many pathogens have developed ...
COPPER CHEMISTRY OF PYRIDYLALKYLBENZAMIDE LIGANDS: MODELING THE CUZ CENTER OF N2OR AND COORDINATION POLYMER CHEMISTRY
(2011)
In nature, the reduction of N2O to N2 is the terminal step of the denitrification process, which is catalyzed by nitrous oxide reductase (N2OR). The catalytic CuZ center was found to be a novel μ4-sulfide bridged ...
DEVELOPING ELECTROOSMOTIC-PUMP-BASED MINIATURIZED DEVICES: TOWARD A LIQUID CHROMATOGRAPHY CARTRIDGE COUPLED WITH MASS SPECTROMETER AND A SUB-PICOLITER PIPETTOR FOR SINGLE CELL SURGERY
(2017-06)
There has been increasing interest on miniaturizing high performance liquid chromatography (HPLC), since it can reduce the costs of instrument manufacturing and perform onsite analysis. The electroosmotic pump (EOP) is one ...
Nitrogenation of Hydrocarbons via Transition-Metal and Non-Metal Catalysis
(2010)
The overall objective in the Nicholas Group's Amination Project is to develop