Browsing OU - Dissertations by Author "Qiu, Yuchen"
Now showing items 1-10 of 10
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COMPREHENSIVE PERFORMANCE EVALUATION AND OPTIMIZATION OF HIGH THROUGHPUT SCANNING MICROSCOPY FOR METAPHASE CHROMOSOME IMAGING
Qiu, Yuchen (2013-12)Specimen scanning is a critically important tool for diagnosing the genetic diseases in today’s hospital. In order to reduce the clinician’s work load, many investigations have been conducted on developing automatic sample ... -
Developing Novel Computer Aided Diagnosis Schemes for Improved Classification of Mammography Detected Masses
Jones, Meredith (2023-12-15)Mammography imaging is a population-based breast cancer screening tool that has greatly aided in the decrease in breast cancer mortality over time. Although mammography is the most frequently employed breast imaging modality, ... -
Development and application of high throughput hydrogen deuterium exchange mass spectrometry for characterizing protein interactions in complex biological samples
Fang, Mulin (2023-05-12)Protein interactions (e.g., protein-protein interactions and protein-ligand interactions) play an important role in regulating the numerous biological processes that dictate cellular activity. The characterization of protein ... -
Exploring cell heterogeneity: applications of single-probe single cell mass spectrometry for subpopulation analysis
Nguyen, Tra (2023-12-15)Mass spectrometry (MS) has become an indispensable tool for transformed metabolomics studies, whereas exploring single-cell metabolomic profiles remains a challenge due to limited techniques and suitable algorithms. This ... -
MODELLING AND VERIFICATION OF THERMOACOUSTIC MEDICAL IMAGING FROM NANOSCOPIC TO MACROSCOPIC RESOLUTIONS
Samant, Pratik (2019-12-13)In this thesis, three main questions regarding the potential of thermoacoustic imaging are answered: 1) what are the conventional resolution limitations of photoacoustic imaging and how can they be extended to enable ... -
Novel Computer-Aided Diagnosis Schemes for Radiological Image Analysis
Chen, Xuxin (2022-05-13)The computer-aided diagnosis (CAD) scheme is a powerful tool in assisting clinicians (e.g., radiologists) to interpret medical images more accurately and efficiently. In developing high-performing CAD schemes, classic ... -
Quantifying the intact proteome: optimization of analytical methods for high-throughput top-down proteomics
Guo, Yanting (2023-05-12)Proteins play an indispensable cellular role within organisms and participate in a majority of biological functions, including enzymatic catalysis, immune reaction, and signaling. Multiple forms of a protein (i.e., ... -
Single-probe Mass Spectrometry Imaging: Applications and Advanced Data Analysis
Tian, Xiang (2019-12)Mass spectrometry imaging (MSI) is becoming a powerful tool in the bioanalytical studies owing to its unique capability to sensitively map the spatial distribution of broad ranges of molecules on biological samples. Due ... -
Single-probe Single Cell Mass Spectrometry Studies: Investigation of Cell Heterogeneity and Quantification of Intracellular Small Molecules
Lan, Yunpeng (2023-12-15)Studying cell heterogeneity can provide a deeper understanding of biological activities, but corresponding studies cannot be performed using traditional bulk analysis methods. The development of diverse single cell bioanalysis ... -
Subjective Evaluation of the In-Line Phase-Sensitive Imaging Systems in Breast Cancer Screening and Diagnosis
Omoumi, Farid (2022-08-04)Breast x-ray imaging remains the gold standard screening tool despite the various imaging modalities. The phase-sensitive breast imaging is an evolving technology that may provide higher diagnostic accuracy and potentially ...