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Transduction of E2F-1 Tat fusion proteins into primary invasive ductal breast carcinoma cell lines and subsequent effects on gene transcription
(2007-05)
Scope and Method of Study: Breast carcinomas harbor specific genetic alterations that contribute to their immortalized state, including overexpression of telomerase and p53 tumor suppressor gene mutations. E2F-1 is a known ...
Defined interactions of protein kinases with Hsp90 and Cdc37
(2005-12)
Scope and Method of Study: Protein kinases function to transduce the countless number of signals that allow a cell to grow and adapt to its environment. A significant number of protein kinases require assistance in being ...
X-ray crystallographic studies of the cytochrome bc1 complex
(2006-12)
Scope and Method of Study: The purpose of this study was to enhance the understanding of the bc1 complex. The method used in this study is x-ray crystallography and protein crystallization.
Characterization of triacylglyceride lipase and mono- and diacylglycerol acyltransferases in Manduca sexta
(2014-07)
Triglyceride (TG) is the main form of lipid storage in the cell. The processes of hydrolysis and synthesis of TG play critical roles the lipid metabolism. Triglyceridelipase(TGL) is a major fat body lipase hydrolyzing TG ...
Development of oligonucleotide-based microarrays for the detection of plant viruses and the first characterization of a plant virus belonging to the family Totiviridae
(2010-12)
Scope and Method of Study: Ongoing studies for discovery of viral species in non-cultivated plants utilize several genomic approaches for systematic unbiased searches for viruses related to known viruses. Some of these ...
Identification of micrornas and their targets in switchgrass, a model cellulosic biofuel plant species
(2010-12)
Scope and Method of Study:
Comparative analysis of microRNAs in Flaveria species of C3, C3-C4 intermediate and C4 photosynthesis
(2017-05)
MicroRNAs (miRNAs) are a group of small non-coding RNAs that negatively regulate expression of their target genes at the posttranscriptional level. The miRNA-mediated gene regulation has emerged as one of the critical modes ...
Modulation of the transcriptional control of the carbon concentration mechanism within Synechocystis sp. PCC 6803
(2010-07)
Scope and Method of Study:
Characterization of the Ferredoxin-1 mRNA instability element(s)
(2005-05)
Light regulates translation and stability of pea Ferredoxin-1 (Fed-1) mRNA in transgenic tobacco plants. Previous work showed that mutation of a (CAUU)4 repeat in the Fed-1 5' UTR abolished light regulated Fed-1 mRNA ...