Browsing The University of Oklahoma by Author "Qiu, Yuchen"
Now showing items 1-12 of 12
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COMPREHENSIVE PERFORMANCE EVALUATION AND OPTIMIZATION OF HIGH THROUGHPUT SCANNING MICROSCOPY FOR METAPHASE CHROMOSOME IMAGING
Qiu, Yuchen (2013-12)Specimen scanning is a critically important tool for diagnosing the genetic diseases in today’s hospital. In order to reduce the clinician’s work load, many investigations have been conducted on developing automatic sample ... -
DETECTABILITY ASSESSMENT OF THE HIGH-ENERGY X-RAY IN-LINE PHASE CONTRAST PROTOTYPE FOR DENSE BREASTS
Guo, Yuran (2018-12-14)The primary objective of the research in this thesis is to evaluate the performance of the high-energy in-line phase contrast prototype with the conventional mammography along with ultrasound systems in the detection of ... -
Developing Novel Computer Aided Diagnosis Schemes for Improved Classification of Mammography Detected Masses
Jones, Meredith (2023-12-15)Mammography imaging is a population-based breast cancer screening tool that has greatly aided in the decrease in breast cancer mortality over time. Although mammography is the most frequently employed breast imaging modality, ... -
Development and application of high throughput hydrogen deuterium exchange mass spectrometry for characterizing protein interactions in complex biological samples
Fang, Mulin (2023-05-12)Protein interactions (e.g., protein-protein interactions and protein-ligand interactions) play an important role in regulating the numerous biological processes that dictate cellular activity. The characterization of protein ... -
Exploring cell heterogeneity: applications of single-probe single cell mass spectrometry for subpopulation analysis
Nguyen, Tra (2023-12-15)Mass spectrometry (MS) has become an indispensable tool for transformed metabolomics studies, whereas exploring single-cell metabolomic profiles remains a challenge due to limited techniques and suitable algorithms. This ... -
MODELLING AND VERIFICATION OF THERMOACOUSTIC MEDICAL IMAGING FROM NANOSCOPIC TO MACROSCOPIC RESOLUTIONS
Samant, Pratik (2019-12-13)In this thesis, three main questions regarding the potential of thermoacoustic imaging are answered: 1) what are the conventional resolution limitations of photoacoustic imaging and how can they be extended to enable ... -
Novel Computer-Aided Diagnosis Schemes for Radiological Image Analysis
Chen, Xuxin (2022-05-13)The computer-aided diagnosis (CAD) scheme is a powerful tool in assisting clinicians (e.g., radiologists) to interpret medical images more accurately and efficiently. In developing high-performing CAD schemes, classic ... -
PREDICTION OF EARLY STAGE LUNG CANCER PROGNOSIS AFTER SURGERY USING A NEW CAD-GENERATED IMAGING MARKER
BOYAPALLY, Venkata Sai Chandra (2018-05-11)Due to cancer heterogeneity, identifying new clinical markers to more effectively predict prognosis of cancer patients plays an important role to improve efficacy of cancer treatment. Objective of this study is to develop ... -
Quantifying the intact proteome: optimization of analytical methods for high-throughput top-down proteomics
Guo, Yanting (2023-05-12)Proteins play an indispensable cellular role within organisms and participate in a majority of biological functions, including enzymatic catalysis, immune reaction, and signaling. Multiple forms of a protein (i.e., ... -
Single-probe Mass Spectrometry Imaging: Applications and Advanced Data Analysis
Tian, Xiang (2019-12)Mass spectrometry imaging (MSI) is becoming a powerful tool in the bioanalytical studies owing to its unique capability to sensitively map the spatial distribution of broad ranges of molecules on biological samples. Due ... -
Single-probe Single Cell Mass Spectrometry Studies: Investigation of Cell Heterogeneity and Quantification of Intracellular Small Molecules
Lan, Yunpeng (2023-12-15)Studying cell heterogeneity can provide a deeper understanding of biological activities, but corresponding studies cannot be performed using traditional bulk analysis methods. The development of diverse single cell bioanalysis ... -
Subjective Evaluation of the In-Line Phase-Sensitive Imaging Systems in Breast Cancer Screening and Diagnosis
Omoumi, Farid (2022-08-04)Breast x-ray imaging remains the gold standard screening tool despite the various imaging modalities. The phase-sensitive breast imaging is an evolving technology that may provide higher diagnostic accuracy and potentially ...