Browsing by Subject "Engineering, Biomedical."
Now showing items 1-20 of 42
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The 2.3A crystal structure of the antibody Fab HPC-4 in complex with calcium and the epitope peptide.
(2007)The murine monoclonal antibody HPC-4, directed against the activation region of the human anticoagulant zymogen protein C (PC), is one of the few immunoglobulins known to display calcium-dependent antigen binding. Unlike ... -
Advancing Annexin-Directed Enzyme Prodrug Therapy for the Treatment of Solid Tumors
(2015-05)By targeting enzymes to the surface of tumor cells, tumor vasculature, and metastatic lesions, annexin-directed enzyme prodrug therapy aims to create high-dose chemotherapy only in the direct vicinity of the tumor site and ... -
Advancing Multimodal Approaches to Study Human Brain: Improvements in Simultaneous EEG-fMRI Acquisition
(2019-12)The primary aim of the study detailed in this dissertation was improving the quality of simultaneous electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) experiments. Two common challenges to use ... -
Annexin A5 - chlorambucil: A targeted therapeutic drug against leukemia and breast cancer
(2018-12-14)Breast cancer is the most common cancer in women worldwide and its incidence is increasing, particularly in developing countries. The survival rate of early stage breast cancer is 80% but falls to 24% for breast cancers ... -
Big-Data Analytics of Human Brain Network Dynamics: A Simultaneous EEG-fMRI Study
(2020-07-30)Psychiatric conditions, such as mood and anxiety, are complex and heterogeneous syndromes that encompass varied, co-occurring symptoms and divergent responses to treatment. To facilitate characterizing the heterogeneity ... -
Blast wave transmission through the ear with computational and 3D printed models and assessment of cochlea damage with SEM imaging
(2021-05-14)Blast-induced injuries affect the health of service members, veterans, and other victims, in which the auditory system is often damaged rupturing the tympanic membrane (TM) and reducing the number of viable cochlear hair ... -
A bone tissue engineering approach based on the combination of biomimetic scaffolds and flow perfusion culture.
(2007)Bone tissue engineering has progressively emerged as a response to the current limited replacement therapies for damaged or lost bone tissue. Ideally, the implanted construct should aid in complete bone regeneration in a ... -
Characterization of Chemically Modified Human Amniotic Membranes for Tissue Engineering Applications
(2018-05)The human amniotic membrane (hAM) is a collagen-based extracellular matrix derived from the human placenta. It is a readily-available, inexpensive, and naturally biocompatible material. Despite its attractive biological ... -
Compartmental bilinear models and tracer techniques in the analysis of biological control systems /
(The University of Oklahoma., 1971) -
COMPUTATIONAL INVESTIGATION OF TURBULENT BLOOD FLOW AND HEMOLYSIS IN BIOMEDICAL DEVICES
(2015-12-18)Turbulent blood flow in medical devices contributes to blood trauma, yet the exact mechanism(s) have not been fully elucidated. Local turbulent stresses, viscous stresses, and the rate of dissipation of the turbulent kinetic ... -
Computer-integrated finite element modeling and simulation of human middle ear.
(2001)The work reported in this dissertation is the result of a joint venture of biomedical scientists and engineers for understanding human middle ear mechanics through finite element modeling and analysis. The main objective ... -
Data balancing approaches in quality, defect, and pattern analysis
(2023-05-12)The imbalanced ratio of data is one of the most significant challenges in various industrial domains. Consequently, numerous data-balancing approaches have been proposed over the years. However, most of these data-balancing ... -
The design and development of a 3D printer compatible bioreactor for tendon tissue engineering
(2016-12)Tendon and ligament tissue engineering aims to provide an alternative tissue graft for patients with acute injuries that require surgical intervention. Alternatives are necessary due to limited availability of allografts ... -
Developing Novel Computer Aided Diagnosis Schemes for Improved Classification of Mammography Detected Masses
(2023-12-15)Mammography imaging is a population-based breast cancer screening tool that has greatly aided in the decrease in breast cancer mortality over time. Although mammography is the most frequently employed breast imaging modality, ... -
DEVELOPMENT AND CHARACTERIZATION OF A HIGH-ENERGY IN-LINE PHASE CONTRAST TOMOSYNTHESIS PROTOTYPE
(2016-12-16)Phase sensitive 3D imaging techniques have been an emerging field in x-ray imaging for two decades. Among them, in-line phase contrast tomosynthesis has been investigated with great potential for translation into clinical ... -
Development and characterization of encapsulated thrombolytic formulations to enhance thrombolysis.
(2003)The potential benefit of MESK was also explored in a canine model of coronary thrombosis, a clinically relevant model of myocardial infarction. Compared to FREE SK (68 +/- 7 min), MESK significantly reduced the time to ... -
Development and Preclinical Evaluation of Enzyme Prodrug Therapies Targeted to the Tumor Vasculature
(2014)Breast cancer is a global health concern of high prevalence that lacks safe and effective therapies for advanced cases. A targeted enzyme prodrug therapy aims to address this issue using an enzyme localized to the tumor ... -
EEG OSCILLATORY ACTIVITIES FROM HUMAN MOTOR BRAIN
(2015-12)Motor skills are essential in people’s daily life in exploring and interacting with the ambient environment. Impairments to motor functions affect the acquisition of motor skills, which not only reduce the quality of ... -
The effects of noise, air ions, and electric fields on living systems /
(The University of Oklahoma., 1968) -
Effects of Short Exposure to High Shear on Neutrophil State and Function
(2018)Cardiovascular disease is an ever expanding global issue. Many pathological conditions have been recently linked to elevated local shear rates (>3,000 s-1). Such vulnerable regions have also been found in mechanical support ...