Browsing by Author "Gappa-Fahlenkamp, Heather"
Now showing items 1-12 of 12
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Design and intracellular trafficking of poly(L-lysine)-grafted-poly(ethylene glycol) fiberless adenoviral gene delivery vector
Gabal, Yasmine (2020-07)The first gene therapy clinical trials were started nearly 30 years ago, but the field only now seems to be on the verge of widespread adoption. Safe and efficient gene delivery, however, is still a major obstacle and is ... -
Design, synthesis and characterization of eumelanin-inspired small molecules and polymers as novel organic semiconductors
Sachinthani, K. A. Niradha (2017-07)Over the past few decades, organic semiconductors (OSCs) have become a rapidly growing research field due to their diverse range of applications in electronics such as organic photovoltaics, organic light emitting diodes, ... -
Development, Characterization, and Optimization of a Multi-Chamber, Single-Use Bioreactor
Amer, Momen (2019-05-01)Stirred-tank single-use bioreactors have proven their capability to successfully replace their stainless-steel counterparts in the biopharmaceutical industry. To date, however, only a five-fold volume expansion is achievable ... -
Effect of monocyte chemoattractant protein-1 concentration gradients on monocyte migration in a three-dimensional in vitro vascular tissue model
Ghousifam, Neda (2015-07)The initiation of atherosclerosis is marked by the accumulation of lipid substances in the subendothelial layer of major arteries, followed by adhesion and transmigration of monocytes to the extracellular matrix (ECM). ... -
Effect of Serum and Cellular Proteins on Hybrid Vector Transduction Efficiency
Karode, Shishir S. (Oklahoma State University, 2010-07-01)Our study involved formation of hybrid vector complex from viral and synthetic parts and studying the effect of presence of proteins on transduction of the hybrid vector. We separated proteins from virus-like particles and ... -
Effective Screening of Chemical Penetration Enhancers for Transdermal Drug Delivery
Rachakonda, Vijay Krishna (Oklahoma State University, 2008-07-01)The potency of a CPE in enhancing the permeation of a drug is usually determined by quantifying the amount of drug permeated through skin in the presence of the CPE. Typically, these experiments are performed in Franz ... -
Polymer adsorption on silica and wettability of graphene oxide surfaces, experiments and simulations
Mortazavian, Hamid (2016-05)Among the various classifications of polymer composites, studying polymers adsorbed to a surface such as silica is important due to their numerous applications. Adsorbed polymers usually show different properties than their ... -
Regulation of placental growth factor by fluid shear stress in the vessel wall
Rashdan, Nabil Aiman (2015-07)Arteriogenesis is the process by which mature arteries form from collateral arterioles after upstream arterial stenosis or occlusion. During collateral remodeling, monocytes are recruited to the vessel wall. Placental ... -
Synthesis and functionalization of poly-l-lysine-grafted-polyethylene glycol copolymer nanoparticle complexes for protein delivery
Flynn, Nicholas (2018-07)Proteins are a large group of biomolecules that are capable of a broad range of biochemical functions. Utilizing the biochemical capabilities of proteins is of significant interest toward improving human health. For proteins ... -
Synthetic strategies for generating inorganic nanoparticles with optical, catalytic, and biological importance
Fernando, Kachchakaduge Deshani Gihanthika (2017-12)Solution-based synthesis methods have been widely used to synthesize nanocrystals as it provides control over the size and shape. As a result of the rapid success of the solution based synthesis methods, new applications ... -
Tissue-engineered model for the study of an allergic inflammatory response
Derakhshan, Tahereh (2018-12-01)Allergy occurs when the immune system overreacts to allergens. Worldwide, up to 40% of the population suffers from different types of allergies. In severe cases, allergic reactions can lead to death. Therefore, determining ... -
Using a Tissue-Engineered Vascular Model to Develop Mast Cells from Stem Cells
Chan, Tszwai Regina (2018-07-01)Over the last few decades, the prevalence of allergic diseases has increased dramatically in developed nations. Mast cells (MCs) play a key role in allergic responses. However, it is difficult to isolate high numbers of ...