Natural and Synthetic Biomaterials for Engineering Multicellular Tumor Spheroids

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dc.contributor.authorKamatar, Advika
dc.contributor.authorGunay, Gokhan
dc.contributor.authorAcar, Handan
dc.date.accessioned2021-02-03T21:25:29Z
dc.date.available2021-02-03T21:25:29Z
dc.date.issued2020-10-28
dc.description.abstractThe lack of in vitro models that represent the native tumor microenvironment is a significant challenge for cancer research. Two-dimensional (2D) monolayer culture has long been the standard for in vitro cell-based studies. However, differences between 2D culture and the in vivo environment have led to poor translation of cancer research from in vitro to in vivo models, slowing the progress of the field. Recent advances in three-dimensional (3D) culture have improved the ability of in vitro culture to replicate in vivo conditions. Although 3D cultures still cannot achieve the complexity of the in vivo environment, they can still better replicate the cell–cell and cell–matrix interactions of solid tumors. Multicellular tumor spheroids (MCTS) are three-dimensional (3D) clusters of cells with tumor-like features such as oxygen gradients and drug resistance, and represent an important translational tool for cancer research. Accordingly, natural and synthetic polymers, including collagen, hyaluronic acid, Matrigel®, polyethylene glycol (PEG), alginate and chitosan, have been used to form and study MCTS for improved clinical translatability. This review evaluates the current state of biomaterial-based MCTS formation, including advantages and disadvantages of the different biomaterials and their recent applications to the field of cancer research, with a focus on the past five years.en_US
dc.description.peerreviewYesen_US
dc.description.sponsorshipThis work is supported in part by the Oklahoma Tobacco Settlement Endowment Trust awarded to the University of Oklahoma, Stephenson Cancer Center. The content is solely the responsibility of the authors and does not necessarily represent the official views of the Oklahoma Tobacco Settlement Endowment Trust. Open Access fees paid for in whole or in part by the University of Oklahoma Libraries.en_US
dc.identifier.citationKamatar A, Gunay G, Acar H. Natural and Synthetic Biomaterials for Engineering Multicellular Tumor Spheroids. Polymers. 2020; 12(11):2506. https://doi.org/10.3390/polym12112506en_US
dc.identifier.doi10.3390/polym12112506en_US
dc.identifier.urihttps://hdl.handle.net/11244/328587
dc.languageen_USen_US
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectMCTSen_US
dc.subjectMulticellular tumor spheroiden_US
dc.subjectThree-dimensional cultureen_US
dc.subjectBiomaterialsen_US
dc.subjectMicroenvironmenten_US
dc.subjectHydrogelen_US
dc.subjectScaffolden_US
dc.subjectBiopolymersen_US
dc.titleNatural and Synthetic Biomaterials for Engineering Multicellular Tumor Spheroidsen_US
dc.typeArticleen_US
ou.groupHealth Sciences Centeren_US

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