The Evolutionary History of Daphniid a-Carbonic Anhydrase within Animalia

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dc.contributor.authorCulver, Billy W.
dc.contributor.authorMorton, Philip K.
dc.date.accessioned2015-04-20T22:24:18Z
dc.date.accessioned2016-03-30T15:36:41Z
dc.date.available2015-04-20T22:24:18Z
dc.date.available2016-03-30T15:36:41Z
dc.date.issued2015
dc.description.abstractUnderstanding the mechanisms that drive acid-base regulation in organisms is important, especially for organisms in aquatic habitats that experience rapidly fluctuating pH conditions. Previous studies have shown that carbonic anhydrases (CAs), a family of zinc metalloenzymes, are responsible for acid-base regulation in many organisms. Through the use of phylogenetic tools, this present study attempts to elucidate the evolutionary history of the α-CA superfamily, with particular interest in the emerging model aquatic organism Daphnia pulex. We provide one of the most extensive phylogenies of the evolution of α-CAs, with the inclusion of 261 amino acid sequences across taxa ranging from Cnidarians to Homo sapiens. While the phylogeny supports most of our previous understanding on the relationship of how α-CAs have evolved, we find that, contrary to expectations, amino acid conservation with bacterial α-CAs supports the supposition that extracellular α-CAs are the ancestral state of animal α-CAs. Furthermore, we show that two cytosolic and one GPI-anchored α-CA in Daphnia genus have homologs in sister taxa that are possible candidate genes to study for acid-base regulation. In addition, we provide further support for previous findings of a high rate of gene duplication within Daphnia genus, as compared with other organisms.en_US
dc.description.peerreviewYesen_US
dc.description.sponsorshipThis study was supported by the U.S. National Science Foundation (NSF-IOS-OEI) grant to L. J. Weider (no. 0924289).en_US
dc.identifier.citationBilly W. Culver and Philip K. Morton, “The Evolutionary History of Daphniid α-Carbonic Anhydrase within Animalia,” International Journal of Evolutionary Biology, vol. 2015, Article ID 538918, 11 pages, 2015. doi:10.1155/2015/538918en_US
dc.identifier.doihttp://dx.doi.org/10.1155/2015/538918en_US
dc.identifier.urihttp://hdl.handle.net/11244/14436
dc.languageen_USen_US
dc.relation.urihttp://www.hindawi.com/journals/ijeb/2015/538918/
dc.subjectevolutionary biology; acid-base regulation in organisms; carbonic anhydrases; phylogenetic toolsen_US
dc.titleThe Evolutionary History of Daphniid a-Carbonic Anhydrase within Animaliaen_US
dc.typeArticleen_US

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