Postmortem distribution of zolpidem in aviation accident victims.

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dc.contributor.advisorvon Minden, David
dc.contributor.authorThompson, Kristi S.
dc.contributor.committeeMemberBost, Robert
dc.contributor.committeeMemberLewis, Russell
dc.date.accessioned2020-05-26T20:40:38Z
dc.date.available2020-05-26T20:40:38Z
dc.date.issued2013
dc.description.abstractThe purpose of the study was to confirm there is a consistent postmortem distribution of zolpidem in postmortem blood and body tissues, and/or fluids making it possible to estimate zolpidem blood concentrations from fluid and tissue concentrations. The samples for the study were zolpidem-positive fatalities located in the CAMI ToxFlo database at the FAA's Bioaeronautical Sciences Research Laboratory. A UPLC/MS method was developed and validated. The LDR, LOD, LOQ, accuracy, precision, and matrix effect were evaluated. The specimens were analyzed for the distribution of zolpidem. The results of this study confirmed there is a consistent postmortem distribution of zolpidem found in the spleen, kidney, and lung; making it possible to roughly estimate, zolpidem blood concentrations from these tissues.
dc.identifier.oclc(OCoLC)ocn857901766
dc.identifier.other(AlmaMMSId)9979369785202196
dc.identifier.urihttps://hdl.handle.net/11244/324761
dc.rightsAll rights reserved by the author, who has granted UCO Chambers Library the non-exclusive right to share this material in its online repositories. Contact UCO Chambers Library's Digital Initiatives Working Group at diwg@uco.edu for the permission policy on the use, reproduction or distribution of this material.
dc.subject.keywordsMethod validation
dc.subject.keywordsPostmortem distribution
dc.subject.keywordsUPLC
dc.subject.lcshZolpidem
dc.subject.lcshAircraft accidents
dc.subject.lcshToxicology
dc.thesis.degreeM.S., Forensic Science
dc.titlePostmortem distribution of zolpidem in aviation accident victims.
dc.typeAcademic theses
thesis.degree.grantorJackson College of Graduate Studies
uco.groupUCO - Graduate Works and Theses::UCO - Theses

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