The Thermoanaerobacter Glycobiome Reveals Mechanisms of Pentose and Hexose Co-Utilization in Bacteria

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dc.contributor.authorLu Lin
dc.contributor.authorHouhui Song
dc.contributor.authorQichao Tu
dc.contributor.authorYujia Qin
dc.contributor.authorAifen Zhou
dc.contributor.authorWenbin Liu
dc.contributor.authorZhili He
dc.contributor.authorJizhong Zhou
dc.contributor.authorJian Xu
dc.date.accessioned2016-01-08T19:47:46Z
dc.date.accessioned2016-03-30T15:32:56Z
dc.date.available2016-01-08T19:47:46Z
dc.date.available2016-03-30T15:32:56Z
dc.date.issued2011-10-13
dc.descriptionen_US
dc.descriptionen_US
dc.description.abstractAuthor Summary Renewable liquid fuels derived from lignocellulosic biomass could alleviate global energy shortage and climate change. Cellulose and hemicellulose are the main components of lignocellulosic biomass. Therefore, the ability to simultaneously utilize pentose and hexose (i.e., co-utilization) has been a crucial challenge for industrial microbes producing lignocellulosic biofuels. Certain thermoanaerobic bacteria demonstrate this unusual talent, but the genetic foundation and molecular mechanism of this process remain unknown. In this study, we reconstructed the structure and dynamics of the first genome-wide carbon utilization network of thermoanaerobes. This transcriptome-based co-expression network reveals that glucose, xylose, fructose, and cellobiose catabolism are each featured on distinct functional modules. Furthermore, the dynamics of the network suggests a distinct yet collaborative nature between glucose and xylose catabolism. In addition, we experimentally demonstrated that these novel network-derived features can be rationally exploited for product-yield enhancement via optimized timing and balanced loading of the carbon supply in a substrate-specific manner. Thus, the newly discovered modular and precisely regulated network elucidates unique features of thermoanaerobic glycobiomes and reveals novel perturbation strategies and targets for the enhanced thermophilic production of lignocellulosic biofuels.en_US
dc.description.peerreviewYesen_US
dc.description.peerreviewnoteshttp://www.plosgenetics.org/static/editorial#peeren_US
dc.identifier.citationLin L, Song H, Tu Q, Qin Y, Zhou A, Liu W, et al. (2011) The Thermoanaerobacter Glycobiome Reveals Mechanisms of Pentose and Hexose Co-Utilization in Bacteria. PLoS Genet 7(10): e1002318. doi:10.1371/journal.pgen.1002318en_US
dc.identifier.doi10.1371/journal.pgen.1002318en_US
dc.identifier.urihttp://hdl.handle.net/11244/23530
dc.language.isoen_USen_US
dc.publisherPLos Genetics
dc.relation.ispartofseriesPLoS Genet 7(10):e1002318
dc.relation.urihttp://www.plosgenetics.org/article/info%3Adoi%2F10.1371%2Fjournal.pgen.1002318
dc.rightsAttribution 3.0 United States
dc.rights.requestablefalseen_US
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/
dc.subjectXylose,Glucose,Thermoanaerobacter,Catabolism,Pentoses,Hexoses,Glucose metabolism,Fructosesen_US
dc.titleThe Thermoanaerobacter Glycobiome Reveals Mechanisms of Pentose and Hexose Co-Utilization in Bacteriaen_US
dc.typeResearch Articleen_US

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