Genetic variation at major histocompatibility complex loci in Neotoma albigula (white-throated woodrat) potential clues to the evolution of North American arenaviruses.

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dc.contributor.advisorHaynie, Michelle L., 1975-
dc.contributor.authorHoss, Sarah G.
dc.contributor.committeeMemberBrennan, Robert
dc.contributor.committeeMemberHellack, Jenna
dc.date.accessioned2020-05-26T20:39:19Z
dc.date.available2020-05-26T20:39:19Z
dc.date.issued2012
dc.description.abstractThe major histocompatibility complex Mhc is an important component of vertebrate immune systems, and as such, genetic analysis of Mhc loci have been shown to provide information on susceptibility to viral infection. Neotoma albigula (white-throated woodrat) are naturally associated with at least 3 arenaviruses, and are considered the putative host species for all 3 viruses. Strains of arenaviruses can cause severe febrile diseases in humans and are considered a serious health risk where human-rodent interactions are common. The association of N. albigula with at least 3 viruses suggests a significant co-evolutionary history between the host and virus. In this study, Mhc loci were screened to detect genetic variation among N. albigula populations in Arizona. This was done to test the prediction that levels of genetic variation at Mhc loci in N. albigula will correlate with specific arenaviral strains. The results have indicated moderate genetic variation among groups but almost no correlation with viral data.--Abstract.
dc.identifier.oclc(OCoLC)ocn839934070
dc.identifier.other(AlmaMMSId)9978514185202196
dc.identifier.urihttps://hdl.handle.net/11244/324719
dc.rightsAll rights reserved by the author, who has granted UCO Chambers Library the non-exclusive right to share this material in its online repositories. Contact UCO Chambers Library's Digital Initiatives Working Group at diwg@uco.edu for the permission policy on the use, reproduction or distribution of this material.
dc.subject.lcshWhite-throated wood rat
dc.subject.lcshMajor histocompatibility complex
dc.subject.lcshViruses
dc.thesis.degreeM.S., Biology
dc.titleGenetic variation at major histocompatibility complex loci in Neotoma albigula (white-throated woodrat) potential clues to the evolution of North American arenaviruses.
dc.typeAcademic theses
thesis.degree.grantorJackson College of Graduate Studies
uco.groupUCO - Graduate Works and Theses::UCO - Theses

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