Effects and mechanisms of auricular electroacupuncture on gastric hypersensitivity in a rodent model of functional dyspepsia

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dc.contributor.authorJingzhu Zhou
dc.contributor.authorShiying Li
dc.contributor.authorYinping Wang
dc.contributor.authorYong Lei
dc.contributor.authorRobert D. Foreman
dc.contributor.authorJieyun Yin
dc.contributor.authorJiande D. Z. Chen
dc.date.accessioned2017-04-10T23:19:05Z
dc.date.available2017-04-10T23:19:05Z
dc.date.issued2017-03-28
dc.descriptionen_US
dc.descriptionen_US
dc.description.abstractBackground Functional dyspepsia (FD) is a common functional gastrointestinal disease, and abdominal pain is one of the main symptoms. The aim of this study was to explore the effects and mechanisms of auricular electro-acupuncture (AEA) on gastric hypersensitivity in a rodent model of FD. Methods Ten-day-old pups were gavaged with 0.2 ml of 0.1% iodoacetamide daily for 6 days. AEA at the “stomach” point with different parameters or sham-EA was performed on 8-week-old animals. Gastric sensitivity to gastric distention was measured under different conditions. Autonomic functions were assessed from the spectral analysis of heart rate variability (HRV) derived from the electrocardiogram. Naloxone was injected intraperitoneally before AEA to explore the opioid mechanism. Gastric emptying was measured at the end of the study. Results 1) Gastric sensitivity to gastric distention was higher in the FD rats. AEA with parameters of 0.1s on, 0.4s off, 100Hz, 0.3ms and 0.4–0.5mA, but not other parameters or sham-EA, decreased gastric hypersensitivity in the FD rats. Naloxone did not block the effect of AEA. 2) Lower vagal activity and higher sympathovagal ratio were noted in the FD rats, compared with the controls. AEA increased vagal activity and improved sympathovagal imbalance. Conclusions AEA ameliorates gastric hypersensitivity in FD rats and this effect may be attributed to the improvement of sympathovagal balance.en_US
dc.description.peerreviewYesen_US
dc.description.peerreviewnoteshttp://www.plosone.org/static/editorial#peeren_US
dc.identifier.citationZhou J, Li S, Wang Y, Lei Y, Foreman RD, Yin J, et al. (2017) Effects and mechanisms of auricular electroacupuncture on gastric hypersensitivity in a rodent model of functional dyspepsia. PLoS ONE 12(3): e0174568. doi:10.1371/journal.pone.0174568en_US
dc.identifier.doi10.1371/journal.pone.0174568en_US
dc.identifier.urihttp://hdl.handle.net/11244/50429
dc.language.isoen_USen_US
dc.publisherPLos One
dc.relation.ispartofseriesPLoS ONE 12(3): e0174568
dc.relation.urihttp://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0174568
dc.rightsAttribution 3.0 United States
dc.rights.requestablefalseen_US
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/
dc.subjectHypersensitivity,Rats,Electromyography,Acupuncture,Opioids,Electrocardiography,Functional electrical stimulation,Rodentsen_US
dc.titleEffects and mechanisms of auricular electroacupuncture on gastric hypersensitivity in a rodent model of functional dyspepsiaen_US
dc.typeResearch Articleen_US

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