Multimodal Imaging Approaches Using Functional Near-infrared Spectroscopy, Electroencephalography and Transcranial Magnetic Stimulation

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dc.contributor.advisorYuan, Han
dc.contributor.authorEdwards, Summer
dc.contributor.committeeMemberDing, Lei
dc.contributor.committeeMemberHavlicek, Joseph
dc.date.accessioned2024-07-22T20:46:46Z
dc.date.available2024-07-22T20:46:46Z
dc.date.issued2024-08-01
dc.date.manuscript2024-07-01
dc.description.abstractSimultaneous functional near infrared spectroscopy (fNIRS) and electroencephalography (EEG) is a neuroimaging device used to record hemodynamic and electrical responses to stimulus. While this imaging system is used amongst many populations, it is used for the first time in epithelial ovarian cancer patients to assess chemotherapy induced cognitive impairment. Before imaging, cognitive side effects were only qualitative in that subjects would report memory loss, brain fog, and general slowness; however, using fNIRS-EEG has quantified the chemotherapy-related changes in neurological function. Upon successful clinical outcomes from fNIRS-EEG, further treatment applications were perused. Thus, fNIRS-EEG was integrated with transcranial magnetic stimulation (TMS) for the first time into a simultaneous neuroimaging and modulating device (fNET). From one successful pilot study, fNET is pioneering the way of many other disease therapies: including depression and glioma treatment. Specifically, fNET is developed to synchronize TMS to alpha phase in real time, which is to be used in new depression therapies. fNET is also developed to aid in brain tumor surgical planning and set healthy baseline connectivity data using working memory paradigms. In this thesis, each of the three experiments are discussed in chronological order to illustrate how multimodal fNET has been developed. By integrating TMS with previously established fNIRS-EEG, neuroimaging possibilities are being engineered into the next standard of clinical care.en_US
dc.identifier.urihttps://hdl.handle.net/11244/340488
dc.subjectneuroimagingen_US
dc.subjectneuromodulationen_US
dc.subjectsignal processingen_US
dc.subjectfunctional near-infrared spectroscopyen_US
dc.thesis.degreeMaster of Scienceen_US
dc.titleMultimodal Imaging Approaches Using Functional Near-infrared Spectroscopy, Electroencephalography and Transcranial Magnetic Stimulationen_US
ou.groupGallogly College of Engineering::Stephenson School of Biomedical Engineeringen_US
shareok.orcid0009-0009-6728-0485en_US

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