Electrochemistry of methylated pterins :
| dc.contributor.author | Ege-serpkenci, Deniz, | en_US |
| dc.date.accessioned | 2013-08-16T12:28:46Z | |
| dc.date.available | 2013-08-16T12:28:46Z | |
| dc.date.issued | 1982 | en_US |
| dc.description.abstract | 6,7-Dimethyl-5,6,7,8-tetrahydropterin (6,7-DMTHP) is an effective and widely used pseudo cofactor for phenylalanine hydroxylase in the hydroxylation reaction of phenylalanine. 6,7-DMTHP and other tetrahydropterins methylated at C(6) and C(7) such as 2-dimethylamino-3,6,7-trimethyl-5,6,7,8-tetrahydropterin (2-DMTHP), 3,6,7,8-tetramethyl-5,6,7,8-tetrahydropterin (3,6,7,8-TMTHP) and 2-dimethylamino-6,7,8-trimethyl-5,6,7,8-tetrahydropterin (2-DMTTHP) give rise to three oxidation peaks at the pyrolytic graphite electrode. Peak I(, a) is an almost reversible 2e-2H('+) oxidation reaction to an unstable quinonoid-dihydropterin. Based on electrochemical, spectroelectrochemical and kinetic results it is believed that this intermediate has an ortho structure. Cyclic voltammetry thin-layer spectroelectrochemistry and potentiostatic experiments reveal that the quinonoid-dihydropterin undergoes a pH-dependent, first-order reaction to give the corresponding 7,8-dihydropterin. Peak II(, a) is due to a 2e-2H('+) quasi-reversible electrooxidation of covalently hydrated 7,8-dihydro derivative giving rise to two unstable quinonoid-dihydropterins which in turn react chemically to give the corresponding pterin. Nonhydrated 7,8-dihydro derivatives are oxidized to the pterin derivative in the peak III(, a) process. | en_US |
| dc.format.extent | xxi, 315 leaves : | en_US |
| dc.identifier.uri | http://hdl.handle.net/11244/5046 | |
| dc.note | Source: Dissertation Abstracts International, Volume: 43-09, Section: B, page: 2890. | en_US |
| dc.subject | Chemistry, Analytical. | en_US |
| dc.thesis.degree | Ph.D. | en_US |
| dc.thesis.degreeDiscipline | Department of Chemistry and Biochemistry | en_US |
| dc.title | Electrochemistry of methylated pterins : | en_US |
| dc.title.alternative | Electrochemical oxidation of 6,7-dimethyltetrahydropterin. | en_US |
| dc.title.alternative | Comparison of electrochemical and spectroelectrochemical behavior of various methylated pterins. | en_US |
| dc.title.alternative | Electrochemical oxidation of 2-dimethylamino-3,6,7-trimethyl-tetrahydropterin. | en_US |
| dc.type | Thesis | en_US |
| ou.group | College of Arts and Sciences::Department of Chemistry and Biochemistry | |
| ou.identifier | (UMI)AAI8302451 | en_US |
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