Plant-Symbiotic Fungi as Chemical Engineers: Multi-Genome Analysis of the Clavicipitaceae Reveals Dynamics of Alkaloid Loci

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dc.contributor.authorChristopher L. Schardl
dc.contributor.authorCarolyn A. Young
dc.contributor.authorUljana Hesse
dc.contributor.authorStefan G. Amyotte
dc.contributor.authorKalina Andreeva
dc.contributor.authorPatrick J. Calie
dc.contributor.authorDamien J. Fleetwood
dc.contributor.authorDavid C. Haws
dc.contributor.authorNeil Moore
dc.contributor.authorBirgitt Oeser
dc.contributor.authorDaniel G. Panaccione
dc.contributor.authorKathryn K. Schweri
dc.contributor.authorChristine R. Voisey
dc.contributor.authorMark L. Farman
dc.contributor.authorJerzy W. Jaromczyk
dc.contributor.authorBruce A. Roe
dc.contributor.authorDonal M. O'Sullivan
dc.contributor.authorBarry Scott
dc.contributor.authorPaul Tudzynski
dc.contributor.authorZhiqiang An
dc.contributor.authorElissaveta G. Arnaoudova
dc.contributor.authorCharles T. Bullock
dc.contributor.authorNikki D. Charlton
dc.contributor.authorLi Chen
dc.contributor.authorMurray Cox
dc.contributor.authorRandy D. Dinkins
dc.contributor.authorSimona Florea
dc.contributor.authorAnthony E. Glenn
dc.contributor.authorAnna Gordon
dc.contributor.authorUlrich Güldener
dc.contributor.authorDaniel R. Harris
dc.contributor.authorWalter Hollin
dc.contributor.authorJolanta Jaromczyk
dc.contributor.authorRichard D. Johnson
dc.contributor.authorAnar K. Khan
dc.contributor.authorEckhard Leistner
dc.contributor.authorAdrian Leuchtmann
dc.contributor.authorChunjie Li
dc.contributor.authorJinGe Liu
dc.contributor.authorJinze Liu
dc.contributor.authorMiao Liu
dc.contributor.authorWade Mace
dc.contributor.authorCaroline Machado
dc.contributor.authorPadmaja Nagabhyru
dc.contributor.authorJuan Pan
dc.contributor.authorJan Schmid
dc.contributor.authorKoya Sugawara
dc.contributor.authorUlrike Steiner
dc.contributor.authorJohanna E. Takach
dc.contributor.authorEiji Tanaka
dc.contributor.authorJennifer S. Webb
dc.contributor.authorElla V. Wilson
dc.contributor.authorJennifer L. Wiseman
dc.contributor.authorRuriko Yoshida
dc.contributor.authorZheng Zeng
dc.date.accessioned2016-01-08T19:47:48Z
dc.date.accessioned2016-03-30T15:31:00Z
dc.date.available2016-01-08T19:47:48Z
dc.date.available2016-03-30T15:31:00Z
dc.date.issued2013-02-28
dc.descriptionWe thank Richard M. Higashi and Teresa W. M. Fan of the University of Louisville Center for Regulatory and Environmental Analytical Metabolomics (supported by NSF EPSCoR grant EPS-0447479), together with Jerome R. Faulkner, University of Kentucky, and for identification of 1-acetamidopyrrolizidine; Abbe Kesterson and Alfred D. Byrd of the University of Kentucky Advanced Genetic Technologies Center for assistance in DNA sequencing; and John May of the University of Kentucky Environmental Research Training Laboratories for assistance in loline alkaloid analysis. This is publication number 13-12-004 of the Kentucky Agricultural Experiment Station, published with approval of the director.en_US
dc.descriptionen_US
dc.description.abstractAuthor Summary The fungal family, Clavicipitaceae, includes “ergot” fungi that parasitize ears of cereals and have historically caused mass poisonings, as well as “epichloae,” which are symbionts of grasses. Many epichloae are mutualistic symbionts, but some are pathogenic, and others have both mutualistic and pathogenic characteristics. Most Clavicipitaceae produce “alkaloids,” small molecules that deter insects, livestock, and wildlife from feeding on the fungus or plant. Epichloae protect their hosts with diverse alkaloids belonging to four chemical classes. After sequencing the entire DNA contents (“genomes”) of ten epichloae, three ergot fungi, and two relatives, we compared their “clusters” of genes for alkaloid biosynthesis. In the epichloae, these clusters contained extraordinarily large blocks of highly repetitive DNA, which promote gene losses, mutations, and even the evolution of new genes. These repeat blocks account for the exceptionally high alkaloid diversity in the epichloae and may relate to the ecological diversity of these symbiotic fungi.en_US
dc.description.peerreviewYesen_US
dc.description.peerreviewnoteshttp://www.plosgenetics.org/static/editorial#peeren_US
dc.identifier.citationSchardl CL, Young CA, Hesse U, Amyotte SG, Andreeva K, Calie PJ, et al. (2013) Plant-Symbiotic Fungi as Chemical Engineers: Multi-Genome Analysis of the Clavicipitaceae Reveals Dynamics of Alkaloid Loci. PLoS Genet 9(2): e1003323. doi:10.1371/journal.pgen.1003323en_US
dc.identifier.doi10.1371/journal.pgen.1003323en_US
dc.identifier.urihttp://hdl.handle.net/11244/23533
dc.language.isoen_USen_US
dc.publisherPLos Genetics
dc.relation.ispartofseriesPLoS Genet 9(2):e1003323
dc.relation.urihttp://www.plosgenetics.org/article/info%3Adoi%2F10.1371%2Fjournal.pgen.1003323
dc.rightsAttribution 3.0 United States
dc.rights.requestablefalseen_US
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/
dc.subjectAlkaloids,Genetic loci,Fungal genomics,Plant genomics,Telomeres,Sequence assembly tools,Fungi,Repeated sequencesen_US
dc.titlePlant-Symbiotic Fungi as Chemical Engineers: Multi-Genome Analysis of the Clavicipitaceae Reveals Dynamics of Alkaloid Locien_US
dc.typeResearch Articleen_US

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