Investigation of Microwave Energy in the Synthesis of Heterocycles Related to Medicinal Chemistry

Abstract

Allowing many chemical reactions to be completed within minutes, microwave technology has revolutionized preparative chemistry. Since it is a green technology, it is becoming widely adopted in both academic and industrial laboratories. Heterocycles are very important functional groups especially in medicinal chemistry. In this research heterocyclic precursors of pharmaceuticals are synthesized using microwave radiation. An important class of heterocyclics, derivatives of isatin (indole-2,3-dione), as well as its Schiff and Mannich bases, have already been reported to show a variety of biological activities, such as antibacterial, antifungal and anti-HIV activities. The wide spectrum of isatin derivatives and their various chemical properties has led to their increasingly expanded use as precursors for the preparation of many biologically active compounds. Hydrazine derivatives of isatin have been found to be active against Walker carcinosarcoma. In this research isatin derivatives were synthesized using microwave technology. Their antimicrobial activity will be tested.