Investigation of Microwave and Ultrasonic Energy in the Synthesis of Heterocycles Related to Medicinal Chemistry

Abstract

Allowing many chemical reactions to be completed within minutes, microwave heating and ultrasonic energy have revolutionized preparative chemistry. Both are green technologies and as a result, are becoming widely adopted in both academic and industrial laboratories. This is especially true for microwave synthesis but not many applications of ultrasonic energy in organic synthesis have been reported. Heterocycles are very important functional groups especially in medicinal chemistry. Not only are they pivotal in the synthesis of drugs but also form part of the structure of a diversity of drugs, vitamins, natural products and biomolecules. In this poster we will present the results of syntheses of imidazoles and azolines by both microwave and ultrasonic energy. Derivatives of these two classes of compounds are known for analgesic, antifungal, antihypertensive, antiobesity, anticancer and other biological activity.