Auditory EEG Biomarkers in Fragile X Syndrome: Clinical Relevance

Simple item page
dc.contributor.authorEthridge, Lauren E.
dc.contributor.authorDe Stefano, Lisa A.
dc.contributor.authorSchmitt, Lauren M,
dc.contributor.authorWoodruff, Nicholas E.
dc.contributor.authorBrown, Karla L.
dc.contributor.authorTran, Morgan
dc.contributor.authorWang, Jun
dc.contributor.authorPedapati, Ernest V.
dc.contributor.authorErickson, Craig A.
dc.contributor.authorSweeney, John A.
dc.date.accessioned2020-05-20T18:52:52Z
dc.date.available2020-05-20T18:52:52Z
dc.date.issued2019-10-09
dc.description.abstractSensory hypersensitivities are common and distressing features of Fragile X Syndrome (FXS). While there are many drug interventions that reduce behavioral deficits in Fmr1 mice and efforts to translate these preclinical breakthroughs into clinical trials for FXS, evidence-based clinical interventions are almost non-existent potentially due to lack of valid neural biomarkers. Local circuit function in sensory networks is dependent on the dynamic balance of activity in inhibitory/excitatory synapses. Studies are needed to examine the association of electrophysiological alterations in neural systems with sensory and other clinical features of FXS to establish their clinical relevance. Adolescents and adults with FXS (n = 38, Mean age = 25.5, std = 10.1; 13 females) and age matched typically developing controls (n = 40, Mean age = 27.7, std = 12.1; 17 females) completed auditory chirp and auditory habituation tasks while undergoing dense array electroencephalography (EEG). Amplitude, latency, and percent change (habituation) in N1 and P2 event-related potential (ERP) components were characterized for the habituation task; time-frequency calculations using Morlet wavelets characterized phase-locking and single trial power for the habituation and chirp tasks. FXS patients showed increased amplitude but some evidence for reduced habituation of the N1 ERP, and reduced phase-locking in the low and high gamma frequency range and increased low gamma power to the chirp stimulus. FXS showed increased theta power in both tasks. While the habituation finding was weaker than previously found, the remaining findings replicate our previous work in a new sample of patients with FXS. Females showed less deficit in the chirp task but not the habituation task. Abnormal increases in gamma power were related to more severe behavioral and psychiatric features as well as reductions in neurocognitive abilities. Replicating electrophysiological deficits in a new group of patients using different EEG equipment at a new data collection site with differing levels of environmental noise that were robust to data processing techniques utilizing multiple researchers, indicates a potential for scalability to multi-site clinical trials. Given the robust replicability, relevance to clinical measures, and preclinical evidence for sensitivity of these EEG measures to pharmacological intervention, the observed abnormalities may provide novel translational markers of target engagement and potentially outcome measures in large-scale studies evaluating new treatments targeting neural hyperexcitability in FXS.en_US
dc.description.peerreviewYesen_US
dc.description.sponsorshipThis study was supported by NIMH/NICHD grant U54 HD082008-01 (Huber and JS). Open Access fees paid for in whole or in part by the University of Oklahoma Libraries.en_US
dc.identifier.citationEthridge LE, De Stefano LA, Schmitt LM, Woodruff NE, Brown KL, Tran M, Wang J, Pedapati EV, Erickson CA and Sweeney JA (2019) Auditory EEG Biomarkers in Fragile X Syndrome: Clinical Relevance. Front. Integr. Neurosci. 13:60. doi: 10.3389/fnint.2019.00060en_US
dc.identifier.doi10.3389/fnint.2019.00060en_US
dc.identifier.urihttps://hdl.handle.net/11244/324427
dc.languageen_USen_US
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectFragile X Syndromeen_US
dc.subjectEEGen_US
dc.subjectchirpen_US
dc.subjecthabituationen_US
dc.subjectgammaen_US
dc.subjectsensoryen_US
dc.titleAuditory EEG Biomarkers in Fragile X Syndrome: Clinical Relevanceen_US
dc.typeArticleen_US
ou.groupCollege of Arts and Sciences::Department of Psychologyen_US

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Ethridge_etal_2019_AuditoryEEGBiomarkersinFragileXSyndromeClinicalRelevance.pdf
Size:
2.96 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.72 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

OU - Faculty and Staff Publications