Sterilization of hydrogen peroxide resistant bacterial spores with stabilized chlorine dioxide

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dc.contributor.authorFriedline, Anthony
dc.contributor.authorZachariah, Malcolm
dc.contributor.authorMiddaugh, Amy
dc.contributor.authorHeiser, Matt
dc.contributor.authorKhanna, Neeraj
dc.contributor.authorVaishampayan, Parag
dc.contributor.authorRice, Charles V.
dc.date.accessioned2015-04-20T22:24:27Z
dc.date.accessioned2016-03-30T15:36:40Z
dc.date.available2015-04-20T22:24:27Z
dc.date.available2016-03-30T15:36:40Z
dc.date.issued2015-04-17
dc.description.abstractBacillus pumilus SAFR-032 spores isolated from a clean room environment are known to exhibit enhanced resistance to peroxide, desiccation, UV radiation and chemical disinfection than other spore-forming bacteria. The survival of B. pumilus SAFR-032 spores to standard clean room sterilization practices requires development of more stringent disinfection agents. Here, we report the effects of a stabilized chlorine dioxide-based biocidal agent against spores of B. pumilus SAFR-032 and Bacillus subtilis ATCC 6051. Viability was determined via CFU measurement after exposure. Chlorine dioxide demonstrated efficacy towards sterilization of spores of B. pumilus SAFR-032 equivalent or better than exposure to hydrogen peroxide. These results indicate efficacy of chlorine dioxide delivered through a stabilized chlorine dioxide product as a means of sterilization of peroxide- and UV-resistant spores.en_US
dc.description.peerreviewYesen_US
dc.description.sponsorshipThis work is supported by the National Institutes of Health (1R01GM090064-01), a NASA EPSCoR Research Infrastructure Development (RID) grant NN07AL49A, and the University of Oklahoma.en_US
dc.identifier.citationFriedline, Anthony, et al. Sterilization of hydrogen peroxide resistant bacterial spores with stabilized chlorine dioxide. AMB Express 2015, 5:24en_US
dc.identifier.doi10.1186/s13568-015-0109-4en_US
dc.identifier.urihttp://hdl.handle.net/11244/14437
dc.languageen_USen_US
dc.relation.urihttp://www.amb-express.com/content/5/1/24
dc.subjectBacillus pumilus ; Bacillus subtilis ; Chlorine dioxide; Spore killing; Sporesen_US
dc.titleSterilization of hydrogen peroxide resistant bacterial spores with stabilized chlorine dioxideen_US
dc.typeArticleen_US

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