An investigation of the anisotropic mechanical properties and anatomical structure of porcine atrioventricular heart valves

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dc.contributor.authorJett, Samuel
dc.contributor.authorKunkel, Robert
dc.contributor.authorBabu, Anju R.
dc.contributor.authorKramer, Katherine
dc.contributor.authorBaumwart, Ryan
dc.contributor.authorTowner, Rheal
dc.contributor.authorWu, Yi
dc.contributor.authorLee, Chung-Hao
dc.contributor.authorLaurence, Devin
dc.date.accessioned2018-10-16T14:56:42Z
dc.date.available2018-10-16T14:56:42Z
dc.date.issued2018
dc.description.abstractValvular heart diseases are complex disorders, varying in pathophysiological mechanism and affected valve components. Understanding the effects of these diseases on valve functionality requires a thorough characterization of the mechanics and structure of the healthy heart valves. In this study, we performed biaxial mechanical experiments with extensive testing protocols to examine the mechanical behaviors of the mitral valve and tricuspid valve leaflets. We also investigated the effect of loading rate, testing temperatures, species (porcine versus ovine hearts), and age (juvenile vs adult ovine hearts) on the mechanical responses of the leaflet tissues. In addition, we evaluated the structure of chordae tendineae within each valve and performed histological analysis on each atrioventricular leaflet. We found all tissues displayed a characteristic nonlinear anisotropic mechanical response, with radial stretches on average 30.7% higher than circumferential stretches under equibiaxial physiological loading. Tissue mechanical responses showed consistent mechanical stiffening in response to increased loading rate and minor temperature dependence in all five atrioventricular heart valve leaflets. Moreover, our anatomical study revealed similar chordae quantities in the porcine mitral (30.5 ± 1.43 chords) and tricuspid valves (35.3 ± 2.45 chords) but significantly more chordae in the porcine than the ovine valves (p < 0.010). Our histological analyses quantified the relative thicknesses of the four distinct morphological layers in each leaflet. This study provides a comprehensive database of the mechanics and structure of the atrioventricular valves, which will be beneficial to development of subject-specific atrioventricular valve constitutive models and toward multi-scale biomechanical investigations of heart valve function to improve valvular disease treatments. This is the post print for the version of record: Jett, Samuel, Devin Laurence, Robert Kunkel, Anju R. Babu, Katherine Kramer, Ryan Baumwart, Rheal Towner, Yi Wu, and Chung-Hao Lee. "An investigation of the anisotropic mechanical properties and anatomical structure of porcine atrioventricular heart valves." Journal of the mechanical behavior of biomedical materials 87 (2018): 155-171. This post print is licensed CC BY-NC-ND and was retrieved from http://www.ou.edu/coe/ame/bbdl/publications.en_US
dc.description.peerreviewYesen_US
dc.identifier.citationJett, Samuel, Devin Laurence, Robert Kunkel, Anju R. Babu, Katherine Kramer, Ryan Baumwart, Rheal Towner, Yi Wu, and Chung-Hao Lee. "An investigation of the anisotropic mechanical properties and anatomical structure of porcine atrioventricular heart valves." Journal of the mechanical behavior of biomedical materials 87 (2018): 155-171.en_US
dc.identifier.doi10.1016/j.jmbbm.2018.07.024en_US
dc.identifier.urihttps://hdl.handle.net/11244/301842
dc.languageen_USen_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectBiaxial mechanical testingen_US
dc.subjectmitral and tricuspid valvesen_US
dc.subjectSoft tissue biomechanics and microstructureen_US
dc.subjectMorphological analysisen_US
dc.titleAn investigation of the anisotropic mechanical properties and anatomical structure of porcine atrioventricular heart valvesen_US
dc.typeArticleen_US
ou.groupCollege of Engineering::School of Aerospace and Mechanical Engineeringen_US

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