Type I Interferons Induce T Regulatory 1 Responses and Restrict Humoral Immunity during Experimental Malaria

Simple item page
dc.contributor.authorRyan A. Zander
dc.contributor.authorJenna J. Guthmiller
dc.contributor.authorAmy C. Graham
dc.contributor.authorRosemary L. Pope
dc.contributor.authorBradly E. Burke
dc.contributor.authorDaniel J.J. Carr
dc.contributor.authorNoah S. Butler
dc.date.accessioned2017-03-05T23:41:04Z
dc.date.available2017-03-05T23:41:04Z
dc.date.issued2016-10-12
dc.descriptionWe thank Christopher Hunter and Bob Axtell for critical feedback, and the Flow Cytometry Laboratory at OUHSC for technical assistance.en_US
dc.descriptionen_US
dc.description.abstractAuthor Summary Humoral immunity is essential for host resistance to pathogens that trigger highly inflammatory immune responses, including Plasmodium parasites, the causative agents of malaria. Long-lived, secreted antibody responses depend on a specialized subset of CD4 T cells called T follicular helper (Tfh) cells. However, anti-Plasmodium humoral immunity is often short-lived, non-sterilizing, and immunity rapidly wanes, leaving individuals susceptible to repeated bouts of malaria. Here we explored the relationship between inflammatory type I interferons, the regulation of pathogen-specific CD4 T cell responses, and humoral immunity using models of experimental malaria and systemic virus infection. We identified that type I interferons promote the formation and accumulation of pathogen-specific CD4 T regulatory 1 cells that co-express interferon-gamma and interleukin-10. Moreover, we show that the combined activity of interferon-gamma and interleukin-10 limits the magnitude of infection-induced Tfh responses, the secretion of parasite-specific secreted antibody, and parasite control. Our study provides new insight into the regulation of T regulatory 1 responses and humoral immunity during inflammatory immune reactions against systemic infections.en_US
dc.description.peerreviewYesen_US
dc.description.peerreviewnoteshttp://www.plospathogens.org/static/editorial#peeren_US
dc.identifier.citationZander RA, Guthmiller JJ, Graham AC, Pope RL, Burke BE, Carr DJ, et al. (2016) Type I Interferons Induce T Regulatory 1 Responses and Restrict Humoral Immunity during Experimental Malaria. PLoS Pathog 12(10): e1005945. doi:10.1371/journal.ppat.1005945en_US
dc.identifier.doi10.1371/journal.ppat.1005945en_US
dc.identifier.urihttp://hdl.handle.net/11244/49301
dc.language.isoen_USen_US
dc.publisherPLoS Pathogens
dc.relation.ispartofseriesPLoS Pathog 12(10): e1005945
dc.relation.urihttp://www.plospathogens.org/article/info%3Adoi%2F10.1371%2Fjournal.ppat.1005945
dc.rightsAttribution 3.0 United States
dc.rights.requestablefalseen_US
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/
dc.subjectT helper cells,Parasitic diseases,Plasmodium,Humoral immunity,Malaria,Malarial parasites,Cloning,Antibodiesen_US
dc.titleType I Interferons Induce T Regulatory 1 Responses and Restrict Humoral Immunity during Experimental Malariaen_US
dc.typeResearch Articleen_US

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
journal.ppat.1005945.pdf
Size:
5.32 MB
Format:
Adobe Portable Document Format
Download

Collections

OU - Faculty and Staff Publications