Advancement of Natural Products: Optimization of Instrumentation and Examples of their Application to the Isolation of New Compounds

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dc.contributor.advisorCichewicz, Robert
dc.contributor.authorMattes, Allison
dc.contributor.committeeMemberStevenson, Bradley
dc.contributor.committeeMemberGlatzhofer, Daniel
dc.contributor.committeeMemberSharma, Indrajeet
dc.contributor.committeeMemberYang, Zhibo
dc.date.accessioned2019-07-17T18:14:36Z
dc.date.available2019-07-17T18:14:36Z
dc.date.issued2019
dc.date.manuscript2019
dc.description.abstractThe world of natural products has a long rich history dating back thousands of years and was the origin of medicine as we know it. Advancements in the field of natural products can be seen not only in the isolation of new molecules, but also in the advancement of new tools that are used to elucidate the structure of new compounds, identify lead compounds, as well as monitor the pharmokinetics of bioactive substances. The third chapter in this dissertation introduces a new tool that could be used in the later steps of drug development by being able to rapidly quantify a fluorinated compound in complex mixtures, the fourth chapter includes a comparison of an advanced spheroid bioassay with the traditional 2D assay that can be used to identify appropriate lead compounds, and the fifth chapter reveals techniques for applying natural products to a less discussed target: agricultural fungicides.en_US
dc.identifier.urihttps://hdl.handle.net/11244/320427
dc.languageenen_US
dc.subjectNatural Productsen_US
dc.subjectDrug Discoveryen_US
dc.subjectNMRen_US
dc.thesis.degreePh.D.en_US
dc.titleAdvancement of Natural Products: Optimization of Instrumentation and Examples of their Application to the Isolation of New Compoundsen_US
ou.groupCollege of Arts and Sciences::Department of Chemistry and Biochemistryen_US
shareok.nativefileaccessrestricteden_US

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